Dexamethasone on Fetal and Uteroplacental Doppler
Phase 2
Completed
- Conditions
- Preterm Birth
- Registration Number
- NCT02662790
- Lead Sponsor
- Assiut University
- Brief Summary
The current study aims to investigate the effects of dexamethasone exerted on fetal and uteroplacental circulation as measured by Doppler ultrasonography in pregnancies at risk for preterm birth after 24 hours of its administration.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 50
Inclusion Criteria
- Patients at risk of preterm labor to be included were those with preterm uterine contractions, placenta previa, and mild preeclampsia
Exclusion Criteria
- Patients who were actively in labor, presented with premature rupture of membranes, intrauterine growth restriction (IUGR), those who had received corticosteroids in their pregnancies and/or fetuses with suspected structural abnormalities
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method mean of Doppler Resistance index (RI) 24 hours
- Secondary Outcome Measures
Name Time Method mean of Doppler Pulsatility index (PI) 24 hours
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie dexamethasone's impact on fetal circulation in preterm birth risk pregnancies?
How does antenatal dexamethasone compare to betamethasone in improving uteroplacental Doppler waveforms for preterm birth prevention?
Which biomarkers correlate with improved fetal Doppler outcomes following dexamethasone administration in high-risk pregnancies?
What adverse events are associated with repeated dexamethasone doses in uteroplacental circulation studies and how are they managed?
Are there combination therapies involving dexamethasone and placental growth factor modulators that enhance preterm birth risk management?
Trial Locations
- Locations (1)
Ahmed Abbas
🇪🇬Assiut, Cairo, Egypt
Ahmed Abbas🇪🇬Assiut, Cairo, Egypt