A comparative study of therapeutic effects of garlic and penicillamine in patients with chronic occupational lead poisoning
Phase 2
- Conditions
- ead poisoning.Toxic effects of lead and its compounds
- Registration Number
- IRCT138804062083N1
- Lead Sponsor
- Research Department, Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 76
Inclusion Criteria
employees who has worked more than one year in a car battery industry, blood lead levels of 200-500 µg/L
Exclusion criteria: family history of allergy to penicillin and drugs that have cross-sensitivity to penicillin, antimalarial drugs and gold salt, history of agranolocytosis or anemia in previous use of penicillamine, known heart, liver or renal failure, hypersensitivity to garlic, hemorrhagic diathesis, elective surgery during and 10 days after the consumption of garlic, using antibiotics or anticoagulant drugs
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood lead levels. Timepoint: Baseline and 1 month after the intervention. Method of measurement: by atomic absorption device, model Perkin Elmer 3030, through the technique of Heated Graphite Atomization.;Signs and symptoms. Timepoint: Baseline and 1 month after the intervention. Method of measurement: medical examination.
- Secondary Outcome Measures
Name Time Method Side effects. Timepoint: routine medical examination to find possible abnormal signs and symptoms - Complete blood count 15 days after the initiation of intervention. Method of measurement: Routine medical examination - Complete blood count 15 days after the initation of treatment.;Blood sugar. Timepoint: Baseline and 1 month after the intervention. Method of measurement: laboratory testing.;Liid profile invluding (cholestrol, triglyceride, HDL and LDL). Timepoint: Baseline and one month after the intervention. Method of measurement: laboratory testing.