RBR-9d8z6m
Active, not recruiting
Phase 3
Open and controlled trial of hydroxychloroquine and azytromicyn use to prevent complications in patients infected by new coronavirus (COVID-19): a randomized controlled trial - Brazil COVID Coalition I Trial
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Hospital do Coração
- Status
- Active, not recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients admitted to the ICU or Hospital with suspected or confirmed COVID\-19
Exclusion Criteria
- •Presence of any of the following: Need to supplement oxygen more than 4L; Use of high flow nasal catheter; Use of non\-invasive ventilation; Use of mechanical ventilation; Use of hidroxichoroquine, chloroquine,
- •azithromycin or other macrolide over 24 hours; History of severe ventricular or QTC equal or grater than 48 ms cardiac arrithmia; History of hepatic desease (cirrosis); Renal dysfunction (estimated glomerular filtration rate \[eGFR] less than 30ml/min/1\.73m2, using MDRD or CKD\-EPI method); Patients with retinopathy or macular degeneration; Children under 18 years;Pregnancy; Allergy to chloroquine and derivatives; Allergy to azythromicyn; Patients in hospital over 48hr; Patients with symptoms over 14 days
Outcomes
Primary Outcomes
Not specified
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