Mapping exposure-induced immune effects: connecting the exposome and the immunome

European Commission0 个研究点目标入组 3,825 人开始时间: 2022年2月1日最近更新: 2024年3月18日

适应症

试验速览

2022 Protocol article in https://pubmed.ncbi.nlm.nih.gov/35169671/ (added 21/11/2022) Other publications in https://doi.org/10.48804/AMZHSD SOP for collection, storage and shipment of biological samples (added 07/02/2023)

•General Adult population
•1. At least 18 years old
•2. Written informed consent must be obtained before any assessment is performed
•Birth cohort
•1. Participants are recruited at the birth of their child. Enrollment of eligible women is performed during all four seasons.
•Occupational study population
•1. Occupational exposure to one of the exposures: mineral dust and/or organic solvents at selected workplaces (UMFST – Romania); Waste workers with a high diversity of microorganisms (NRCWE – Denmark); Park workers in the city of Barcelona (VHIR – Spain)
•Control group of office workers, matched to age and gender.
•1. At least 18 years old
•2. Written informed consent must be obtained before any assessment is performed
•Disease cohorts
•1. Clinically active cases of sarcoidosis or Systemic sclerosis (KU Leuven), Systemic sclerosis, Systemic Lupus Erythematosus and Rheumatoid arthritis (UCL), active hypersensitivity pneumonitis (VHIR) or AID (Note: patients are recruited in the following hospitals: University hospital of Leuven, University hospital of Louvain, Vall d’Hebron University Hospital)
•Control group for disease cohorts
•1. At least 18 years old
•2. With or without treatment
•3. Written informed consent must be obtained before any assessment is performed

•General Adult population:
•1. Immunomodulator / immunosuppressive treatments
•Birth cohort:
•1. Not being able to fill out a questionnaire
•2. Not a singleton pregnancy
•3. Having a planned caesarean section
•Occupational study population
•1. Younger than 18
•2. Pregnancy
•3. Unwillingness or inability to wear air samplers, and fill-out questionnaire-based health surveys
•4. Immunomodulator / immunosuppressive treatments
•5. Less than 1 year of employment to the selected workplaces
•Disease cohorts
•1. Younger than 18
•2. Specific criteria may include wearers of metal prostheses (sarcoidosis), or Previous diagnosis in case of hypersensitivity pneumonitis

发起方