The Effect of of Vancomycin powder and Povidon-Iodine in the Prevention of Wound infection in Open Lower-limb Fractures Undergoing Open Reduction and Internal Fixation

Esfahan University of Medical Sciences0 个研究点目标入组 40 人开始时间: 待定最近更新: 2022年1月11日

适应症

试验速览

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•Diagnosis of open fracture and the need for open reduction and internal fixation surgery
•The patient should not be referred to the operating room as a vital emergency and should be fasted for 8 hours before the operation
•Age between 18 and 65 years
•Having a body mass index between 18 and 25
•Not pregnant during the study
•Lack of sensitivity to seafood
•No autoimmune diseases and immune system defects (Guillain-Barre, multiple sclerosis, immune deficiency syndrome, etc.)
•Not having any declining bone disease
•Do not take antibiotics one week before surgery
•No skin diseases
•No history of orthopedic and neurosurgery during the last 6 months
•Absence of cIII degree open fractures in Gastillo Anderson classification
•No smoking and drug addiction
•Lack of underlying and autoimmune diseases (diabetes, multiple sclerosis, immune deficiency syndrome, etc.)
•No previous allergy to antibiotics and disinfectants
•Informed consent

•Intraoperative blood transfusion
•Unforeseen events before surgery such as cardiac arrest and death
•Patient death during study (within 30 days after surgery)
•Bleeding more than 200 cc
•Duration of surgery more than 2 hours
•Arbitrary use of antibiotics without a doctor's prescription
•The interval between going to the emergency room and surgery is more than 23 hours
•Reluctance to continue participating in research

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