Hypersensitivity in Eosinophilic Esophagitis

Completed

Conditions: allergic esophagitis
Eosinophilic esophagitis
10017969

Registration Number: NL-OMON49677

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 17

Inclusion Criteria

- Previous diagnosis of active EoE confirmed by histopathology e.g. presence of
>15 eosinophilic granulocytes per high power field (hpf) in esophageal biopsies
- Written informed consent
- Age 18-75 years

Exclusion Criteria

- Any form of treatment for EoE (topical corticosteroids, PPI or dietary
treatment) in the month preceding the study
- ASA class III, IV or V
- The need for pain medication 24 hours before the visit

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Measures of sensitivity of the esophagus:<br /><br>1. Perfusion sensitivity scores in histological active disease, disease in<br /><br>remission and healthy controls, calculated via [(total perfusion time * lag<br /><br>time to perception) x maximum VAS]<br /><br><br /><br>2. Balloon pressure that induced a sensation of discomfort in histological<br /><br>active disease, disease in remission and healthy controls</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Esophageal barrier function in histological active disease and disease in<br /><br>remission, defined as electrical tissue impedance measured with ETIS and<br /><br>transepithelial electrical resistance and fluorescein flux measured in Ussing<br /><br>chamber<br /><br><br /><br>2. The degree of reflux in the EoE patients, as measured with 24-hours pH-<br /><br>impedance measurement </p><br>