Attenuation of hemodynamic response of laryngoscopy and suppression of stress response during laproscopic cholecystectomy in patients premedicated with oral clonidine versus oral atenolol:A Prospective Randomised Placebo Controlled Trial
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 156
- 试验地点
- 1
- 主要终点
- To compare perioperative hemodynamic changes in heart rate and blood pressure
研究概览
简要总结
Laryngoscopy and intubation are potent stressful stimuli and lead to various hemodynamic responses like increase in heart rate blood pressure
Pneumoperitoneum created during laproscopic surgeries also lead to various stress responses These changes are harmful for certain patients like those with hypertension coronary artery disease heart blocks geriatric population
So in order to attenuate these stress responses we have certain drugs like alpha agonists beta blockers benzodiazepines calcium channel blockers
Alpha 2 agonists like clonidine decrease blood pressure by decreasing sympathetic tone and reducing circulating catecholamines They also have analgesic effects
Beta blockers like atenolol also inhibit sympathetic stimulation and are used to attenuate the stress response
The purpose of this study is to compare the perioperative hemodynamic changes in heart rate and blood pressure and to compare the requirement of additional beta blockers
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA I & ASA II, normotensive patients undergoing laparoscopic cholecystectomy.
排除标准
- •ASA III & IV , Hypersensitivity to Atenolol or clonidine SBP less than 100 mmhg heart rate less than 60 per min & more than 120 per min recent myocardial infarction coronary artery disease conduction defect obstructive airway disease second or third degree heart block patient already on antihypertensive medication.
结局指标
主要结局
To compare perioperative hemodynamic changes in heart rate and blood pressure
时间窗: Perioperative changes in heart rate and blood pressure will be monitored at baseline, at the time of receiving drug, when patient is shifted to OT, at intubation and then at 3 minute intervals till 15 minutes post intubation, then at every 15 minutes till extubation.
To compare the requirement of additional beta blockers
时间窗: Perioperative changes in heart rate and blood pressure will be monitored at baseline, at the time of receiving drug, when patient is shifted to OT, at intubation and then at 3 minute intervals till 15 minutes post intubation, then at every 15 minutes till extubation.
次要结局
- To compare postoperative recovery(To compare postoperative nausea and vomiting)
研究者
Kumari Sonali
Rajendra Institute of Medical Sciences