A comparative trial studying the molecular action of vitamin D and retinoids (acitretin) in children with autosomal recessive congenital ichthyosis
- Conditions
- Health Condition 1: null- autosomal recessive congenital ichthyosis with vitamin D Deficiency
- Registration Number
- CTRI/2017/08/009565
- Lead Sponsor
- Department of Science Technology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
1.All patients of autosomal recessive congenital ichthyosis belonging to either lamellar or congenital ichthyosiform erythroderma phenotypes.
Lamellar Ichthyosis:
a. Children with large parchment like scales all over the body
b. Scales are larger, severely thicker and brownish that might fracture resulting in tessellated or tile like pattern.
c. Hyperkeratotic and more verrucous scaling around the joints
d. Erythroderma
e. Severe ectropion
Congenital Ichthyosiform erythroderma
f. Prominent erythroderma
g. Scaling is present all over the body, less severe than seen in lamellar phenotype.
h. Scales are lighter and thinner
2.Serum 25 (OH) D levels < 20 ng/mL with or without rickets
3.Age > 6 months
1.Other variants of congenital Ichthyosis (Ichthyosis vulgaris, X linked recessive ichthyosis, epidermolytic ichthyosis)
2.Children with liver and kidney impairment or any other systemic illness.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method