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临床试验/NCT04362228
NCT04362228已完成不适用

The Effects of Whole-body Exercise to Improve Swallowing Function in Older Adults With Dementia

McMaster University1 个研究点 分布在 1 个国家目标入组 9 人开始时间: 2021年5月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
9
试验地点
1
主要终点
Change in respiratory function from baseline to end of intervention

研究概览

简要总结

Swallowing impairment (dysphagia) is extremely common in older adults living with dementia due to age-related changes in swallowing and other disease-specific impairments. Dysphagia is commonly managed by modifying diet textures rather than engaging in rehabilitative swallowing therapy. This means that countless people with dementia are left to eat pureed foods and drink thickened liquids, which are unpalatable and lead to malnutrition. As the disease progresses, many are transferred to nursing homes. In Canada, speech-language pathologists, who manage dysphagia, are consultants within nursing homes; therefore, swallowing therapy is non-existent. However, exercise therapy is more commonly available. Rodent models have demonstrated that physical exercise strengthens tongue and vocal-fold musculature, which are critical components of swallowing. Therefore, it is possible that whole-body physical exercise, which increases rate of respiration, will help to strengthen swallowing-related musculature in older adults with dementia. In this study, older adults (65+) with early-stage dementia will complete a 12-week physical exercise program to determine improvement of swallowing function.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Treatment
盲法
None

入排标准

年龄范围
60 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •> 59 years of age
  • •able to walk independently with or without an assistive device for a distance of at least 10 meters
  • •able to be active for 60 minutes with rest breaks
  • •abe to independently follow directions
  • •not involved in active rehabilitation
  • •a diagnosis of a progressive neurologic disease
  • •a maximum value for tongue strength <40 kPa

排除标准

  • •neurological conditions other than a progressive neurologic disease
  • •significant cardiovascular conditions
  • •severe aphasia
  • •pain, other medical conditions or behavioural issues that would limit safe participation in the exercise program
  • •individuals with known structural causes of dysphagia
  • •individuals with known allergies to latex
  • •individuals receiving swallowing rehab

研究组 & 干预措施

Whole-body exercise

Experimental

干预措施: Whole-body exercise (Behavioral)

结局指标

主要结局

Change in respiratory function from baseline to end of intervention

时间窗: baseline, week 4, week 14 and week 16

Measure via peak cough flow using a peak flow meter

Change in swallowing function from baseline to end of intervention

时间窗: baseline, week 4, week 14 and week 16

Measure via isometric tongue strength using an Iowa Oral Performance Instrument

次要结局

  • Change in aerobic fitness from baseline to end of intervention(baseline, week 4, week 14 and week 16)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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