Postprandial Lipid Metabolism in Patients With Hypertriglyceridemia and Normo-lipidemic Controls: Medium Chain Fatty Acids (MCT) in Comparison to Long-chain, Saturated Fatty Acids (SFA) and Mono-unsaturated Fatty Acids (MUFA)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- postprandial hypertriglyceridemia
研究概览
简要总结
Postprandial lipid metabolism will be evaluated in patients with hypertriglyceridemia and normo-lipidemic controls; different fats will be used (saturated fatty acids, mon-unsaturated fatty acids and medium chain fatty acids) for the oral fat challenge.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •hypertriglyceridemia (150 mg/dl-900 mg/dl)
排除标准
- •Lipid lowering drugs or indication for Lipid lowering drugs
- •LDL-cholesterol > 190 mg/dl
- •Diabetes mellitus
研究组 & 干预措施
MCT
subjects start with MCT fat load
干预措施: SFA (Other)
MCT
subjects start with MCT fat load
干预措施: MUFA (Other)
SFA
subjects start with SFA fat load
干预措施: SFA (Other)
SFA
subjects start with SFA fat load
干预措施: MUFA (Other)
MUFA
subjects start with MUFA fat load
干预措施: SFA (Other)
MUFA
subjects start with MUFA fat load
干预措施: MUFA (Other)
MUFA
subjects start with MUFA fat load
干预措施: MCT (Other)
SFA
subjects start with SFA fat load
干预措施: MCT (Other)
MCT
subjects start with MCT fat load
干预措施: MCT (Other)
结局指标
主要结局
postprandial hypertriglyceridemia
时间窗: 8 hours after fat meal
area under the curve following oral fat load
次要结局
未报告次要终点
研究者
Klaus Parhofer
Professor of Endocrinology and Metabolism
Ludwig-Maximilians - University of Munich