A Multi-Center, Double-Blind, Vehicle Controlled, Phase II Study of JNJ 10229570-AAA for the Treatment of Acne Vulgaris
Overview
- Phase
- Phase 2
- Intervention
- 1.2% JNJ 10229570-AAA
- Conditions
- Acne Vulgaris
- Sponsor
- Bausch Health Americas, Inc.
- Enrollment
- 431
- Locations
- 17
- Primary Endpoint
- Change in Total Acne Lesion Counts
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
A study to determine if three different doses of a new acne treatment are safe and better at reducing facial acne than a treatment without active ingredient.
Detailed Description
Approximately 400 male and female subjects with moderate facial acne vulgaris will be enrolled in this randomized, multi-center study. Following satisfaction of entry criteria and screening procedures, subjects will be randomized to either 1.2%, 2.4%, or 3.6% facial cream (JNJ 10229570-AAA) or color-matched vehicle. Subjects will apply the study medication once daily on the face for 12 weeks. Safety will be monitored throughout the study duration. Efficacy will be assessed by facial lesion counts and by the investigator global evaluation of acne severity at Baseline and at Weeks 2, 4, 6, 8, 10, and 12. Approximately 50 subjects from one investigational site also will have serums collected at Weeks 6 and 12 for evaluation of the multiple dose pharmacokinetics of JNJ 10229570-AAA cream.
Investigators
Eligibility Criteria
Inclusion Criteria
- •12 years of age or older, with moderate facial acne vulgaris as defined in the protocol
- •If female of childbearing potential, must take a pregnancy test and have a negative result
- •Females of childbearing potential must also agree to use an adequate method of birth control, which would include:
- •systemic birth control (Subjects must have been taking the same type of birth control for at least 3 months prior to entering the study and must not change type of birth control during the study)
- •Condom with spermicide
- •IUD. Females who have had a hysterectomy, bilateral oophorectomy or bilateral tubal ligation are not required to use additional birth control methods
Exclusion Criteria
- •Known sensitivity to any of the ingredients in the study medication
- •More than 3 nodulocystic acne lesions
- •Use of acne treatments, therapies or medications within protocol-specified timeframes
- •Presence of other skin conditions, diseases, or medical conditions that (per protocol or in the opinion of the investigator) may require concurrent therapy, interfere with the evaluation of the study medication, or compromise subject safety
- •Excessive facial hair that may interfere with application of the medication and/or evaluations
Arms & Interventions
1.2% Facial Cream
1.2% JNJ 10229570-AAA
Intervention: 1.2% JNJ 10229570-AAA
2.4% Facial Cream
2.4% JNJ 10229570-AAA
Intervention: 2.4% JNJ 10229570-AAA
3.6% Facial Cream
3.6% JNJ 10229570-AAA
Intervention: 3.6% JNJ 10229570-AAA
0% Facial Cream
Vehicle control
Intervention: Vehicle control
Outcomes
Primary Outcomes
Change in Total Acne Lesion Counts
Time Frame: Baseline to Week 12
Change in lesion counts between baseline and end of study
Secondary Outcomes
- Change From Baseline in the Inflammatory Acne Lesion Counts(Baseline through Week 12)
- Percent Change From Baseline in the Non-Inflammatory Acne Lesion Counts(Baseline through Week 12)
- Percent Change From Baseline in the Inflammatory Acne Lesion Counts(Baseline through Week 12)
- Change From Baseline in the Non-inflammatory Acne Lesion Counts(Baseline through Week 12)
- Percent Change From Baseline in Total Acne Lesion Counts(Baseline through Week 12.)