A Comparative Clinical Study on the Efficacy of JoshandaHaleela Siyah with Tila-e-Tukhm Turb and Tukhm Jarjir vsTukhm Kharpazah and Aard Baqla in Kalaf (Melasma)

Diagnosed cases of Melasma fulfilling the inclusion criteriawill be enrolled into clinical trial after obtainingwritten informed consent, then they will be randomly allocated into two groupseach 23; viz Group A will receivelocal application of Tila of Tukhme Turb and Tukhme Jarjir and Group B Tilaof Aad Baqla and Tukhmekharpazah, both groups will be given Joshanda Haleela Siyah orally alongwith hot water vapors fomentation.Assessment of outcome will be carried out with m-MASI Score and pGA Scale, photography of the lesions and Dermoscopy on 0 (baseline) 7th , 14th and on 21th day of the trial followed by Post trial follow u will made on 28th day to findout any residual effect of the therapy. Drugsafety will be ensured by monitoring the haematological and serologicalindicators. Efficacy analysis will be performed on Intention-to-treat (ITT)basis using the last observation carry forward method(LOCF) on participants those received all the dosesof both test and comparator drugs and underwent at least two assessment post baseline. The study data will be analyze statistically with appropriate test. Pvalues of last than 0.05 will be considered statistically significant .