The Effect of Environmental Pollution on the Prognosis of Gastric Cancer

Completed

• Conditions: Gastric Cancers

• Registration Number: NCT06686966
• Lead Sponsor: First Affiliated Hospital of Chongqing Medical University

Brief Summary

Gastric cancer is one of the common malignant tumours worldwide, with a high incidence especially in East Asia. Although the occurrence of gastric cancer is closely related to genetic factors, lifestyle and dietary habits, in recent years, environmental pollution, especially air pollution, has received more and more attention as a potential carcinogenic factor. Numerous studies have shown that harmful substances in the air such as including passive smoking, soot and oil smoke exposure, incense burning exposure, occupational exposure and outdoor work, PM2.5, PM10, nitrogen oxides, sulphur dioxide, etc. may not only induce the occurrence of gastric cancer, but also affect the prognosis of gastric cancer patients. This experiment intends to determine the extent of the influence of air pollution on the prognosis of gastric cancer by analysing the survival data of gastric cancer patients in areas with different pollution levels. In addition, the association between air pollution levels and postoperative recurrence in gastric cancer patients was investigated to find possible mechanisms.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01-01
• Status Verified: 2024-11
• Primary Completion: 2024-11-01
• Study Completion: 2024-11-01
• Study First Submitted: 2024-11-12
• Study First Submitted QC: 2024-11-12
• Last Update Submitted: 2024-11-12
• Study First Posted: 2024-11-13
• Last Update Posted: 2024-11-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 3400

Inclusion Criteria

• patients aged ≥18 years;
• patients diagnosed with gastric cancer by pathological biopsy before surgery;
• patients without chemotherapy, radiotherapy, targeted and immunotherapy before enrolment;
• willing to participate in this study and sign the informed consent;
• complete clinical data.

Exclusion Criteria

• patients with other primary malignant tumours other than gastric cancer;
• patients with systemic diseases such as severe cardiopulmonary insufficiency that affect the choice of treatment plan;
• patients who are not suitable for enrolment as assessed by the investigator;
• incomplete clinical data.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the incidence of gastric cancer	From 18 years old until the developing gastric cancer, through study completion, an average of 5 year.	the diagnosis time of gastric cancer