Impact of Intraoperative Perfusion Variability on Postoperative Troponin Elevation in Geriatric Patients Undergoing Major Oncologic Surgery
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Postoperative Troponin Elevation
研究概览
简要总结
This prospective observational study aims to evaluate the association between intraoperative perfusion variability and postoperative troponin elevation in geriatric patients undergoing major oncologic surgery. Intraoperative hemodynamic and perfusion-related parameters will be recorded, and postoperative troponin levels will be assessed to investigate whether intraoperative perfusion changes are associated with myocardial injury. Troponin measurements will be obtained preoperatively and at 24 hours after surgery
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 65 years or older
- •Undergoing major abdominal oncologic surgery
- •Availability of preoperative and 24-hour postoperative troponin measurements
- •Complete intraoperative and postoperative patient monitoring records
- •Provision of written informed consent
排除标准
- •Age younger than 65 years
- •Absence of preoperative or 24-hour postoperative troponin measurements
- •Incomplete intraoperative or postoperative patient monitoring records
- •Undergoing emergency surgery
- •Advanced heart failure
- •ASA Physical Status IV
- •Pulmonary artery pressure >40 mmHg
研究组 & 干预措施
Geriatric Patients Undergoing Major Oncologic Surgery
Geriatric patients undergoing elective major oncolojic surgery will be prospectively observed.Intraoperative hemodynamic and perfusion-related parameters will be recorded, and serum troponin levels will be measured preoperatively and 24 hours after surgery to evaluate the association between intraoperative perfusion variability and postoperative troponin elevation.
结局指标
主要结局
Postoperative Troponin Elevation
时间窗: Preoperatively and 24 hours after surgery
Postoperative troponin elevation will be assessed by comparing serum troponin levels measured preoperatively and 24 hours after surgery. Its association with intraoperative perfusion variability will be evaluated.
Change in Serum Troponin Concentration From Preoperative Baseline to 24 Hours After Surgery
时间窗: Preoperatively and 24 hours after surgery
Postoperative troponin elevation will be assessed by comparing serum troponin levels measured preoperatively and 24 hours after surgery. Its association with intraoperative perfusion variability will be evaluated.
次要结局
- Association Between Intraoperative Perfusion Index and Postoperative Troponin Elevation(Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively)
- Association Between Intraoperative Pleth Variability Index and Postoperative Troponin Elevation(Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively.)
- Association Between Intraoperative Cerebral Oxygen Saturation and Postoperative Troponin Elevation(Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively.)
研究者
Özlem Kapusuz
Principal Investigator
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital