Effects of Exercise on Thyroid Stimulating Hormone Among Class-I Obese Patients With Diabetes Mellitus and Lipid Disorders
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 96
- 试验地点
- 1
- 主要终点
- Thyroid Stimulating Hormone
研究概览
简要总结
Obesity is characterized by an excessive accumulation of body fat that gives rise to significant comorbidities, such as diabetes, hypertension, dyslipidemia, cardiovascular disease, and many cancers. According to WHO, Obesity is a worldwide epidemic, with an estimated 57.8% of adults worldwide expected to be classified as obese by 2030. Therefore, obesity is invariably referred to as a crucial public health problem that requires urgent attention to prevent obesity-related health outcomes. Thyroid dysfunction is often accompanied by changes in body weight and body composition, leading to obesity.
The rising risk of obesity has created susceptibility for every individual irrespective of age, gender and demography. Hence, the focus of researchers is now shifting to devising preventive strategies from the treatment approaches for obesity. To guide healthcare professionals in treating obesity, several guidelines from The Obesity Society (TOS) have been prepared that outline multiple therapies like lifestyle modifications, increased physical activities, dietary modifications, use of medications and in some cases, even surgeries are recommended. However, poor receptivity of exercise among the general population required healthcare professionals to design an exercise program that could be cost and time-effective for the patient. Hence, the present study aims to determine the effect of exercise and the documentation of the best possible exercise regime that could increase TSH among the class I obese population.
详细描述
The study is a randomized controlled trial. The participants were recruited via the envelop method of simple random sampling technique into four groups: Moderate Intensity Continuous Training (MICT), Resistance Training (RT), High-Intensity Interval Training (HIIT) and ½ HIIT.
The training was based on a warm-up session of 5 to 10 minutes followed by conditioning and a cool-down phase of 5 to 10 minutes. The detailed description of each phase is as follows:
Warmup Warm-up exercises, including High Knee and Jumping Jack Exercises, were performed 5 to 10 minutes using the Lindstrom protocol to increase core body temperature and improve blood.
Conditioning Conditioning includes exercises that were performed by the participants under the supervision of a Qualified senior Physical Therapist for varied duration of time depending on the protocol of training.
Moderate Intensity Continuous Training Moderate-intensity endurance exercises were performed by the participants under the supervision of a Qualified senior Physical Therapist by using either a treadmill or cycle ergometer. Exercise frequency was 3 days per week for 16 weeks, each session lasting for 30 minutes. The intensity was calculated using the Karovonean method10, in which a targeted heart rate of 60-85% was maintained for the purpose of conditioning.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Class I obese population BMI ≥25.0 -30.0
- •Young adults aged 20-40 years
- •Diagnosed patients with DM and dyslipidemia.
排除标准
- •Patients diagnosed with pre-existing heart conditions, major illness (acute or chronic), beta-blockers, pregnant or lactating women, and smokers, including any that would limit the ability to perform the necessary exercises, will be excluded from the study.
结局指标
主要结局
Thyroid Stimulating Hormone
时间窗: 16 weeks
The levels of TSH were measured using blood sample (Biodata Diagnostic brand RIA kit)12. The samples were taken twice once before the start of the training protocol and second after the completion of 16 weeks of training. The difference in the values between the groups was used to evaluate the impact of exercises thyroid hormone levels in the body.
次要结局
未报告次要终点
研究者
Batool Hassan
Assistant Professor
Ziauddin University