The persisting effect of episodic exercise training in patients with chronic heart failure.

Withdrawn

Conditions: Chronic heart failure
10019280

Registration Number: NL-OMON33578

Lead Sponsor: Onze Lieve Vrouwe Gasthuis

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 135

Inclusion Criteria

Inclusion criteria p 10
* Symptomatic systolic heart failure (documented clinical signs and symptoms of heart failure) documented for more than 3 months.
* Left ventricular ejection fraction (EF) less than 40% estimated by 2D echocardiography.
* New York Heart Association (NYHA) class: II and III.
* Age between 18- 80 years
* Clinically stable with regard to symptoms and optimal medical therapy for more than 2 weeks prior to inclusion.

Exclusion Criteria

exclusion criteria p 11
* Orthopedic, peripheral vascular or neurological disease limiting the ability to exercise
* Documented exercise-induced ischemia
* Documented exercise-induced ventricular tachycardia
* Poorly controlled cardiac arrhythmias
* Significant chronic pulmonary disease limiting the ability to exercise
* Uncontrolled hypertension
* Abnormal blood pressure response to exercise testing (systolic blood pressure >250 mmHg or diastolic blood pressure >120 mmHg.) Or blood pressure drop of > 20mmHg during baseline exercise test.
* Major anemia
* Aortic valve stenose
* Co morbidity that contraindicate exercise
* Terminal disease
* Patients who can*t speak/understand or read the Dutch language

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Improvement of the functional capacity and to determine the prolonged effects<br /><br>of this intervention.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secundairy endpoints are:<br /><br><br /><br>Serum levels of NT-proBNP<br /><br>serum levels of CRP<br /><br>Quality of live (assessed with MLHFQ)<br /><br>Glycocalyx thickness measured with SDF.<br /><br>Left ventricular ejection fraction</p><br>