A Retrospective Study on the Treatment of Intermediate and Advanced Liver Cancer.

Recruiting

• Conditions: Carcinoma, Hepatocellular
• Interventions: Other: Immunotherapy, targeted therapy.

• Registration Number: NCT06205732
• Lead Sponsor: Qianfoshan Hospital

Brief Summary

To evaluate the effectiveness of TACE combined with immunotherapy and targeted therapy versus TACE alone in patients with intermediate and advanced liver cancer.

Detailed Description

To evaluate the efficacy and safety of TACE combined with immunotherapy and targeted therapy in patients with intermediate and advanced liver cancer. Explore the factors affecting the prognosis of liver cancer treated with TACE combined with immunotherapy and targeted therapy and establish a specific individualized prognostic score and risk stratification model.

Study Timeline

• Status Verified: 2024-01
• Study Start: 2024-01-01
• Study First Submitted: 2024-01-04
• Study First Submitted QC: 2024-01-12
• Last Update Submitted: 2024-01-12
• Study First Posted: 2024-01-16
• Last Update Posted: 2024-01-16
• Primary Completion: 2024-12
• Study Completion: 2024-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• ≥18 years old, both men and women
• primary liver cancer confirmed by liver biopsy or history of hepatitis B, AFP, and typical imaging findings
• patients with liver function Child-Pugh A or B (≤8 points)
• BCLC stage B and stage C
• expected survival time ≥8 weeks
• patients with generally good performance status (ECOG PS score 0 or 1)

Exclusion Criteria

• The patient's key data is missing
• liver metastatic cancer confirmed by histology or cytology
• patients who interrupt treatment due to intolerance of adverse drug reactions
• combined with primary malignant tumors of other organs within 5 years; combined with other serious diseases, such as severe heart disease, renal insufficiency, severe infection, bleeding, etc.
• combined with systemic infection, autoimmune disease, or other types of tumors; previous allogeneic bone marrow transplantation or solid organ transplantation
• study participants known to have mental illness
• situations such as drug use or substance abuse

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
TACE+PD-(L)1+TKI	Immunotherapy, targeted therapy.	Application of TACE, TKI, and immunotherapy in patients with intermediate and advanced liver cancer.

Primary Outcome Measures

Name	Time	Method
Progression-Free-Survival	12 months	From date of randomization until the date of first documented progression or date of death from any cause, whichever came first.

Trial Locations

Locations (1)

the Qianfoshan Hospital; 🇨🇳 Jinan, Shandong, China