Validation of echocardiographic features in foetuses

Recruiting

• Conditions: long QT syndrome; LQTS; 10007521

• Registration Number: NL-OMON55695
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 140

Inclusion Criteria

* The mother must be living in The Netherlands.
* The mother is between 18 and 40 years of age.
* The mother should be pregnant and have had standard obstetric care without
abnormalities

Exclusion Criteria

* Maternal medical history of conditions that are at risk for affecting the
foetus (i.e pregestational diabetes, epilepsy, HIV, hepatitis B)
* Maternal use of medication that affects the QTc-interval
(https://crediblemeds.org/pdftemp/pdf/CombinedList.pdf)
* Foetuses of consanguineous parents
* Foetuses with congenital heart disease, chromosomal syndromes, cephalic
disorders
* Maternal cigarette or alcohol usage during pregnancy
* Maternal obesity before pregnancy (BMI * 30)
* Abnormalities on the previous foetal ultrasound.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The LVIRT and the myocardial contraction duration will be measured using<br /><br>respectively echocardiographic Doppler tracings and cTDI at a foetal age around<br /><br>20, 28 and 30 weeks* gestation.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Other mechanical foetal echocardiographic parameters at 20, 28 en 30 weeks'<br /><br>gestation. </p><br>