The Effects of Aerobic Exercise Training in Patients With Cardiovascular Diseases Related to Microvascular Endothelium Function, Angiogenesis, Oxidative Stress and Aerobic Capacity

Instituto Nacional de Cardiologia de Laranjeiras1 site in 1 country115 target enrollmentDecember 2014

ConditionsCardiovascular Diseases

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Cardiovascular Diseases
Sponsor: Instituto Nacional de Cardiologia de Laranjeiras
Enrollment: 115
Locations: 1
Primary Endpoint: Changes in Skin microvascular blood flow
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This study evaluates the effects of different volumes of aerobic exercise training in cardiovascular parameters of patients with cardiovascular diseases enrolled in a cardiac rehabilitation program.

Detailed Description

Aerobic exercise training is well known to improve endothelium dependent vasodilatation in the microcirculation. However, the impact of exercise frequency on this response in patients with coronary artery disease remains unclear.

Registry

clinicaltrials.gov

Start Date

December 2014

End Date

December 2016

Last Updated

9 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Instituto Nacional de Cardiologia de Laranjeiras

Responsible Party

Principal Investigator

Juliana Pereira Borges

PhD

Instituto Nacional de Cardiologia de Laranjeiras

Eligibility Criteria

Inclusion Criteria

•sedentarism for at least 6 months;
•clinical diagnosis for coronary artery disease (occurrence of any acute coronary syndrome, including ST elevation or non-ST elevation myocardial infarction or unstable angina or by the diagnosis of obstructive coronary artery disease on coronary angiography in patients with stable angina).

Exclusion Criteria

•nephropathies;
•decompensated cardiovascular diseases;
•liver diseases.

Outcomes

Primary Outcomes

Changes in Skin microvascular blood flow

Time Frame: Change from baseline in skin microvascular blood flow at 6 months

Measured through a Laser Speckle Contrast Imaging equipment

Secondary Outcomes

Change in weight(Change from baseline in weight at 6 months)
Change in peak oxygen consumption(Change from baseline in peak oxygen consumption at 6 months)