Multimodal Monitoring Study in Neuro Critical Care

Recruiting

• Conditions: Subarachnoidal Hemorrhage; Acute Trauma Brain Injury; Intacranial Hypertension

• Registration Number: NCT06900101
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

During the first week after an acute cerebral injury, neurologic clinical exam is often irrelevant, limited by sedation use or spontaneous consciousness disorders.

Hence, neurological monitoring of brain oxygen consumption, metabolic disorders, electrical activity is used to follow and prevent delayed cerebral injuries. Among those instruments, numerous are often described: intra cranial pressure monitoring, brain tissue oxygen pressure monitoring, scalp electroencephalography, continuous electroencephalography and Near infrared Red Spectroscopy (NIRS).

Even if the value of some of those technologies are well known, many remain part of a research domain. Here we will not only try to study the correlation between different cerebral autoregulation's index described in the scientific literature but also will we try to identify and describe EEG and cardiorespiratory changes during the first week following brain injury. The objective of this study is to investigate the pathophysiology of acute brain injury and explore potent biomarkers of multimodal monitoring during the first week following acute brain injury.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-01
• Status Verified: 2025-03
• Study First Submitted: 2025-03-21
• Study First Submitted QC: 2025-03-21
• Last Update Submitted: 2025-03-21
• Study First Posted: 2025-03-28
• Last Update Posted: 2025-03-28
• Primary Completion: 2030-12-01
• Study Completion: 2030-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• • Patients hospitalized in neurologic critical care in Wertheimer Hospital, Bron
• Monitored with the CNS MOBERG® monitoring system

Exclusion Criteria

• • Refusal to participate
• Patients under legal protection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between ORx and PRx	Multimodal neuro monitoring is used from 1 to 15 days after the acute brain injury.

Trial Locations

Locations (1)

Hopital Pierre Wertheimer; 🇫🇷 France, Bron, France