Comparison of diaphragmatic atrophy in patients on ventilatory support with SIMV plus PS mode and ACMV mode: A prospective randomized controlled trial

Lakshminarayana Yaddanapudi1 site in 1 country42 target enrollmentStarted: February 5, 2017Last updated: November 23, 2017

Conditions

Trial Snapshot

Phase: Phase 3
Status: Recruiting
Sponsor
Enrollment: 42
Locations: 1
Primary Endpoint: Decrease in diaphragmatic thickness measured by ultrasound

Study Overview Study Design Eligibility Criteria Outcomes Investigators Sites Records & Identifiers Similar Trials

Study Overview

Brief Summary

Patients receiving mechanical ventilation in the ICU suffer from diaphragmatic atrophy, which is usually maximal by the third day of ventilation. This atrophy can pose problems in weaning of the patient from ventilation. Synchronised Intermittent Mandatory Ventilation with Pressure Support and Assist-Control Mechanical Ventilation are two comon modes of ventilation in critically ill patients. This study aims to quantify and compare the degree of atrophy with these two modes of ventilation.

Study Design

Study Type: Interventional
Allocation: Permuted block randomization, variable
Masking: Participant Blinded

Eligibility Criteria

Ages: 18.00 Year(s) to 65.00 Year(s) (—)
Sex: All

Inclusion Criteria

•Patients requiring mechanical ventilation after admission to ICU.

Exclusion Criteria

•Mechanical ventilation (invasive and noninvasive) before coming into ICU
•Patients who are not started on enteral feeding within 24 hours of coming into ICU
•Patients with known neuromuscular disorders and anatomical malformations of the thorax
•Patients with neuroparalytic snake bite
•Patients with organophosphorous compound poisoning 6.

Outcomes

Primary Outcomes

Decrease in diaphragmatic thickness measured by ultrasound

Time Frame: 1st day of ventilation | 3rd day of ventilation (72 hours after the first measurement)

Secondary Outcomes

Duration of ventilation(At the time of transfer from the ICU)

Investigators

Sponsor

Lakshminarayana Yaddanapudi

Sponsor Class

Other [The main supervisor of the thesis]

Study Sites (1)

Loading locations...

Similar Trials

Not yet recruiting

Phase 3

Difference in diaphragmatic thickness in patients on two type of mechanical ventilationRespiratory failure, unspecified,

CTRI/2020/12/030022Postgraduate institute of medical education and research62

Completed

Not Applicable

Diaphragmatic Atrophy Related to Mechanical VentilationAcute Respiratory DistressSeptic Shock

NCT02766946Centre Hospitalier Saint Joseph Saint Luc de Lyon97

Completed

Not Applicable

Ultrasound of Diaphragmatic Musculature in Mechanically Ventilated Patients.Mechanical Ventilation

NCT03281785Mansoura University93

Completed

Not Applicable

Ultrasound of the Diaphragm in ICU PatientsCritically Ill

NCT01952262Università Vita-Salute San Raffaele40

Completed

Not Applicable

ICU Acquired Neuromyopathy and Diaphragm FunctionCritical Illness MyopathyRespiratory Paralysis

NCT01968889University Hospital, Montpellier60