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Clinical Trials/CTRI/2017/11/010621
CTRI/2017/11/010621RecruitingPhase 3

Comparison of diaphragmatic atrophy in patients on ventilatory support with SIMV plus PS mode and ACMV mode: A prospective randomized controlled trial

Lakshminarayana Yaddanapudi1 site in 1 country42 target enrollmentStarted: February 5, 2017Last updated:
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Conditions

Trial Snapshot

Phase
Phase 3
Status
Recruiting
Sponsor
Enrollment
42
Locations
1
Primary Endpoint
Decrease in diaphragmatic thickness measured by ultrasound
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

Patients receiving mechanical ventilation in the ICU suffer from diaphragmatic atrophy, which is usually maximal by the third day of ventilation. This atrophy can pose problems in weaning of the patient from ventilation. Synchronised Intermittent Mandatory Ventilation with Pressure Support and Assist-Control Mechanical Ventilation are two comon modes of ventilation in critically ill patients. This study aims to quantify and compare the degree of atrophy with these two modes of ventilation.

Study Design

Study Type
Interventional
Allocation
Permuted block randomization, variable
Masking
Participant Blinded

Eligibility Criteria

Ages
18.00 Year(s) to 65.00 Year(s) (—)
Sex
All

Inclusion Criteria

  • •Patients requiring mechanical ventilation after admission to ICU.

Exclusion Criteria

  • •Mechanical ventilation (invasive and noninvasive) before coming into ICU
  • •Patients who are not started on enteral feeding within 24 hours of coming into ICU
  • •Patients with known neuromuscular disorders and anatomical malformations of the thorax
  • •Patients with neuroparalytic snake bite
  • •Patients with organophosphorous compound poisoning 6.

Outcomes

Primary Outcomes

Decrease in diaphragmatic thickness measured by ultrasound

Time Frame: 1st day of ventilation | 3rd day of ventilation (72 hours after the first measurement)

Secondary Outcomes

  • Duration of ventilation(At the time of transfer from the ICU)

Investigators

Sponsor
Lakshminarayana Yaddanapudi
Sponsor Class
Other [The main supervisor of the thesis]

Study Sites (1)

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