Comparison of diaphragmatic atrophy in patients on ventilatory support with SIMV plus PS mode and ACMV mode: A prospective randomized controlled trial

Lakshminarayana Yaddanapudi1 个研究点分布在 1 个国家目标入组 42 人开始时间: 2017年2月5日最近更新: 2017年11月23日

适应症

试验速览

阶段: 3 期
状态: 招募中
发起方
入组人数: 42
试验地点: 1
主要终点: Decrease in diaphragmatic thickness measured by ultrasound

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Patients receiving mechanical ventilation in the ICU suffer from diaphragmatic atrophy, which is usually maximal by the third day of ventilation. This atrophy can pose problems in weaning of the patient from ventilation. Synchronised Intermittent Mandatory Ventilation with Pressure Support and Assist-Control Mechanical Ventilation are two comon modes of ventilation in critically ill patients. This study aims to quantify and compare the degree of atrophy with these two modes of ventilation.

研究设计

研究类型: Interventional
分配方式: Permuted block randomization, variable
盲法: Participant Blinded

入排标准

年龄范围: 18.00 Year(s) 至 65.00 Year(s)（—）
性别: All

入选标准

•Patients requiring mechanical ventilation after admission to ICU.

排除标准

•Mechanical ventilation (invasive and noninvasive) before coming into ICU
•Patients who are not started on enteral feeding within 24 hours of coming into ICU
•Patients with known neuromuscular disorders and anatomical malformations of the thorax
•Patients with neuroparalytic snake bite
•Patients with organophosphorous compound poisoning 6.

结局指标

主要结局

Decrease in diaphragmatic thickness measured by ultrasound

时间窗: 1st day of ventilation | 3rd day of ventilation (72 hours after the first measurement)

次要结局

Duration of ventilation(At the time of transfer from the ICU)

研究者

发起方

Lakshminarayana Yaddanapudi

申办方类型

Other [The main supervisor of the thesis]

研究点 (1)

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