Measurement of decrease in thickness of diaphragm in patients on artificial ventilation
Phase 3
Recruiting
- Conditions
- Critically ill patients admitted to the ICU requiring mechanical ventilatory support
- Registration Number
- CTRI/2017/11/010621
- Lead Sponsor
- Lakshminarayana Yaddanapudi
- Brief Summary
Patients receiving mechanical ventilation in the ICU suffer from diaphragmatic atrophy, which is usually maximal by the third day of ventilation. This atrophy can pose problems in weaning of the patient from ventilation. Synchronised Intermittent Mandatory Ventilation with Pressure Support and Assist-Control Mechanical Ventilation are two comon modes of ventilation in critically ill patients. This study aims to quantify and compare the degree of atrophy with these two modes of ventilation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- All
- Target Recruitment
- 42
Inclusion Criteria
Patients requiring mechanical ventilation after admission to ICU.
Exclusion Criteria
- Mechanical ventilation (invasive and noninvasive) before coming into ICU 2.
- Patients who are not started on enteral feeding within 24 hours of coming into ICU 3.
- Patients with known neuromuscular disorders and anatomical malformations of the thorax 4.
- Patients with neuroparalytic snake bite 5.
- Patients with organophosphorous compound poisoning 6.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Decrease in diaphragmatic thickness measured by ultrasound 1st day of ventilation | 3rd day of ventilation (72 hours after the first measurement)
- Secondary Outcome Measures
Name Time Method Duration of ventilation At the time of transfer from the ICU
Trial Locations
- Locations (1)
PGIMER
🇮🇳Chandigarh, CHANDIGARH, India
PGIMER🇮🇳Chandigarh, CHANDIGARH, IndiaLakshminarayana YaddanapudiPrincipal investigator9815836656narayana.yaddanapudi@gmail.com