Cognition and Ultrasound

Not Applicable

Recruiting

• Conditions: Healthy Participants

• Registration Number: NCT07220655
• Lead Sponsor: University of Minnesota

Brief Summary

Our primary goal is to investigate the role of Low-Intensity Focused Ultrasound (LIFU) neuromodulation on deep brain targets, and its potential to improve cognition

Detailed Description

Not available

Study Timeline

• Study Start: 2024-06-01
• Status Verified: 2025-10
• Study First Submitted: 2025-10-22
• Study First Submitted QC: 2025-10-22
• Last Update Submitted: 2025-10-22
• Study First Posted: 2025-10-24
• Last Update Posted: 2025-10-24
• Primary Completion: 2028-07-01
• Study Completion: 2028-07-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• 18 years of age or older
• Speak English (as assessed by their ability to read/answer survey questions)
• May be required to score in the appropriate range on self-report measures

Exclusion Criteria

• They have a neurological disorder which may impact their fMRI scan or cause their reaction to LIFU to differ from that of healthy adults.
• They take any psychoactive medication.
• They are unable to undergo fMRI scanning due to a contraindication such as claustrophobia, unremovable piercings, pregnancy, the presence of medical devices such as pacemakers, or a movement or sleep disorder.
• Are pregnant, or may have reason to believe that they are pregnant.
• They have a diagnosis of a psychiatric condition other than depression or anxiety

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Deep Brain Targets Reached	Hour 1	MRI-based readouts testing whether LIFU neuromodulation can successfully engage targets in deep brain
Multi-Source Interference Test (MSIT) Performance	Hour 1	Behavioral readouts of successful LIFU neuromodulation of our target regions
28/Posit Science Performance	Hour 1	Behavioral readouts of successful LIFU neuromodulation of our target regions

Trial Locations

Locations (1)

University of Minnesota; 🇺🇸 Minneapolis, Minnesota, United States