Clinical Assessment of Chitosan Nanoparticles on Periodontal Problems Post Steroidal Inhalation in Asthmatic Patients: Phase I Trial
- Registration Number
- NCT06525363
- Lead Sponsor
- Deraya University
- Brief Summary
Periodontal problems management is the most important goals of chronic asthmatic patients that adapted to use steroid inhalation for long time. Gram negative anaerobic bacteria are generally suggested as the primary cause of Periodontal problems and mechanical procedure is the treatment approach, which is performed nonsurgical or surgically. The understanding of the role of bacteria in the initiation and progression of periodontal disease has led to great interest in the use of antibiotics to suppress or eradicate pathogenic macrobiotic. Systemic antibiotics have been used in different forms of periodontal disease treatment. Systemic antibiotics can penetrate soft tissues and may target invasive organisms, can be used to treat multiple sites simultaneously, and may also affect reservoirs of bacterial reinfection such as saliva, the tonsils, and the oral mucosa. However, there may be problems associated with the use of systemic antibiotics such as the development of resistant bacteria, and potential side effects (hypersensitivity reactions, gastrointestinal discomfort, etc.). so in this study we aimed at To evaluate the effect of chitosan nanoparticle spray in management of dental problems in asthmatic patients receiving corticosteroids inhaler that support the growth of bacteria in periodontal area.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 20
- Age from 18-50 years old
- Both sex male and female
- Patients diagnosed as Asthmatic
- Patients treated with corticosteroids inhaler or ( beta2-adrenergic agonist inhaler or nebulizer for their symptoms)
- Patients treated with other medication
- Patients not diagnosed as asthmatic
- Comorbidity
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description treatment group Chitosan chitosan nanoparticles spray 1% w/w twice daily
- Primary Outcome Measures
Name Time Method Levels of oral Streptococcus mutans each 3 weeks for 12 weeks counting number of of S. mutans will be obtained by culture and be expressed in colony forming units (CFUs)
Plaque Examination each 3 weeks for 12 weeks Plaque is recorded using the plaque index (PI)
The inflammatory status of the gingiva each 3 weeks for 12 weeks recorded using the gingival index (GI)
- Secondary Outcome Measures
Name Time Method