agasaki Investigation of Candesartan Effects -the Comparison Between an Increased Candesartan and the additional Diuretics
- Conditions
- Hypertension
- Registration Number
- JPRN-UMIN000003978
- Lead Sponsor
- Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 100
Not provided
Exclusion criteria comprised any of the following: (1)Patients under treatments with antihypertensive agents except diuretics who will not continue to take 8mg/day of candesartan for at least 3 months. (2)Administration of diuretics or of agents influencing rennin-angiotensin-aldosterone system except for candesartan. (3)Concomitant medications which are expected to be frequently changed. (4)Under treatment of insulin for diabetes. (5)Severe renal dysfunction (eGFR<30 mL/min/1.73m2) (6)Heart failure (NYHA classification III or IV) (7)Malignant hypertension and secondary hypertension. (8)Myocardial infarction, stroke, and revascularization therapies of coronary arteries and/or peripheral arteries within 6 months prior to the registration of this study. (9)Pregnant female (10)Allergic disorder which is problem in the clinical setting. Hypersensitivity or contraindication to candesartan or hydrochlorothiazide. (11)Patients who are judged by doctors as inappropriate patients for the entries of this study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in blood pressure values in outpatient clinic. Changes in the levels of urine microalbumin, NT-proBNP, high-sensitive CRP, and HbA1c.
- Secondary Outcome Measures
Name Time Method Flow mediated dilation Augmentation index