Organization and Development of Motor Cortical Circuits for Speech Production in Stuttering

Not Applicable

Not yet recruiting

• Conditions: Stutter; Stuttering, Adult; Stuttering; Stuttering, Developmental

• Registration Number: NCT07180628
• Lead Sponsor: University of Michigan

Brief Summary

The overall objective of this study is to examine inter effector areas (IEAs) activity and functional connectivity during continuous speech production in stuttering adults.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-09
• Study Start: 2025-09-01
• Study First Submitted: 2025-09-05
• Study First Submitted QC: 2025-09-11
• Last Update Submitted: 2025-09-11
• Study First Posted: 2025-09-18
• Last Update Posted: 2025-09-18
• Primary Completion: 2030-03
• Study Completion: 2030-03-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Are between the ages of 18-65 years
• Have otherwise normal speech, language, hearing and cognition
• Speak English as their primary language
• Currently stutter

Exclusion Criteria

• Have serious medical or neurological conditions (e.g., stroke, traumatic brain injury, Parkinson's disease, etc.)
• Have had a closed head injury (e.g., concussion)
• Have a reading disorder (e.g., dyslexia)
• Have hearing loss
• Have metal or electronic implants (e.g., cochlear implants, pacemakers, etc.)
• Are currently pregnant

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Blood-Oxygen-Level-Dependent (BOLD) signal change during speaking	During the speech task (5 runs, 8 minutes each) distributed across MRI Visits 1-6, up to 12 months from enrollment.	The Blood-oxygen-level-dependent (BOLD) signal reflects changes in blood oxygenation levels that are associated with neural activity. It is measured using functional magnetic resonance imaging (fMRI) and reported in arbitrary units (a.u.). The BOLD response provides an indirect index of localized brain activity during task performance, with increased signal indicating greater activation in a given brain region relative to baseline or a comparison condition. In this study, BOLD signal differences will be compared within participants across two speech production tasks: (1) stuttered speech and (2) non-stuttered speech. Each participant will complete the speech task on several of the MRI visits, which varies per participant (total amount of time spent will be the same across participants).

Trial Locations

Locations (1)

University of Michigan; 🇺🇸 Ann Arbor, Michigan, United States