Pheochromocytoma randomised study comparing adrenoreceptor Inhibiting agents for preoperative treatment (PRESCRIPT)
Completed
- Conditions
- pheochromocytoma - tumor which produces stresshormones (epinephrine and norepinephrine)1000135310014710
- Registration Number
- NL-OMON41372
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 134
Inclusion Criteria
o age > 18 years
o diagnosis of benign PCC (adrenal or extra-adrenal, sporadic or hereditary)
- elevated plasma and/or urinary (nor)metanephrines
- localisation of PCC by anatomical (MRI/CT) and functional imaging (I123-MIBG scintigraphy or 18F-DOPA PET)
o planned for surgical removal of the PCC
o size of PCC on anatomical imaging =/ > 1 cm in diameter
Exclusion Criteria
o age < 18 years
o malignant PCC, i.e. presence of lesions on imaging studies suggestive of distant metastases
o severe hemodynamic instability before surgery necessitating admission to intensive care unit
o pregnancy
o incapability to adhere to the study protocol
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is defined as the number of patients demonstrating<br /><br>more than three intraoperative episodes of 5 minutes with blood pressure<br /><br>outside the predefined target range after pretreatment with either<br /><br>phenoxybenzamine or doxazosin.</p><br>
- Secondary Outcome Measures
Name Time Method