Social Cognition Dysfunctions in Parkinson's Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Parkinson Disease
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Emotional resonance task score
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Parkinson's disease (PD) is usually responsible of cognitive and behavioral non-motor signs with a major impact on the quality of life. Social cognition is a complex system relying on emotion recognition (neurons mirror system (NMS)), the theory of mind (with its two parts: emotional and cognitive), but also on the social and cultural environment and the personal history. The first step in this model is represented by the NMS, which seems to be altered in PD patients for both positive and negative emotions as shown in our preliminary study. The investigator purpose is to investigate the role of the treatment (levodopa and deep brain stimulation) on the functioning of the NMS
Investigators
Eligibility Criteria
Inclusion Criteria
- •For all participants:
- •Man or woman
- •Participant not objecting to participation in the study
- •Age ≥ 30 and ≤ 70 years old
- •Specific inclusion criteria for patients:
- •Patients with Parkinson's disease with motor fluctuations and dyskinesias receiving deep-brain stimulation
- •Patients able to understand the issues of the study
Exclusion Criteria
- •For all participants:
- •Person deprived of liberty by judicial or administrative decision
- •Person subject to a legal protection measure (tutorship, curatorship)
- •Person concurrently participating in another research project who may interfere with the results or conclusions of this study
- •Specific exclusion criteria for healthy volunteers
- •Person presenting or having presented a neurological or psychiatric pathology
- •Person with a serious medical condition
- •Person who has exceeded the annual amount of compensation authorized for participation in research protocols
Outcomes
Primary Outcomes
Emotional resonance task score
Time Frame: 12 months following the inclusion
In the emotional resonance task, patients are asked to rate the emotional valence of fifteen 3-second silent videos. These movies show emotionally connoted motor interactions between two persons, each of them being depicted by 20 white dots moving on a black background (Point Light Displays (PLD) technique). Among these 15 videos, 5 has a negative valence (making someone cry, sadness, argument, hitting someone and anger), 5 has a positive valence (joy, dancing, giving a flower, laughing and cuddling) and 5 neutral valences (sit, stand, say hello, raise your arms and saw). The Emotional resonance score in parkinsonian patients undergoing treatment (dopaminergic or deep brain stimulation) will be compared to their score without treatment (OFF Dopa or OFF stimulation).
Secondary Outcomes
- Correlations between the emotional resonance task score and patients' quality of life self-questionnaire score (PDQ39)(12 months following the inclusion)