Effectiveness of photobiomodulation pre-conditioning for prevention of oral mucositis in children aged between 2 to 15 years receiving chemotherapy - a randomized controlled trial

Oral mucositis (OM) is one of the most painful and debilitating complications experienced by patients undergoing chemotherapy, with incidence rates particularly being elevated in children. OM impacts 40–100% of patients based on cancer type and treatment modality, pediatric patients exhibit even greater susceptibility, with literature estimating rates as high as 52–80% substantially exceeding compared with 40-76% in adult populations receiving similar therapies. It significantly affects nutrition, oral hygiene, speech, and overall quality of life.

Photobiomodulation (PBM), also known as low-level laser therapy, is a non-invasive technique that uses light in the visible to near-infrared spectrum to influence biological processes. It has garnered attention due to its analgesic, anti-inflammatory, and regenerative effects, while being safer and more child-friendly compared to pharmacological approaches.

This study proposes a randomized controlled trial to evaluate the effectiveness of laser photobiomodulation preconditioning in reducing the occurrence of oral mucositis in children receiving chemotherapy, compared to routine oral hygiene practices alone. These findings may help establish a non-invasive, safe, and effective preventive strategy for children undergoing chemotherapy.