Early versus late time-restricted feeding: its effect on metabolic disease risk factors in adults at increased risk of developing type 2 diabetes

niversity of Surrey0 个研究点目标入组 51 人开始时间: 2019年8月1日最近更新: 2023年1月9日

适应症

试验速览

暂无简介。

•Participants must:
•1. Be aged 18 – 65 years old
•2. Have a BMI = 25 kg/m2
•3. Have maintained a stable body weight for the 6 months preceding the study (± 2 kg)
•4. Be at increased/moderate/high risk of developing type 2 diabetes, as per the Diabetes UK Diabetes Risk Score (scoring = 7)
•5. Be able and willing to give informed oral and informed written consent
•6. Complete and meet the defined criteria of pre-study questionnaires
•7. Be able and willing to complete daily sleep and food diaries during the study
•8. Have an eating period of = 12 hours a day
•9. Agree to eat their meals within certain time periods during the day whilst participating in the study
•10. Be willing and able to undertake laboratory tests on agreed dates during the study

•Participants will be excluded if they:
•1. Have a specific medical condition as confirmed by pre-study questionnaires – Type 1 or 2 diabetes, Polycystic Ovary Syndrome (PCOS), Schizophrenia, Bipolar illness, Depression or receiving treatment with antipsychotic medication, or have a history of Cardiovascular Disease (myocardial infarction or stroke)
•2. Are currently on certain medications: weight loss, glucose- or lipid-lowering medication (e.g. ‘Metformin’ or ‘Statins’), hypnotics or melatonin supplements
•3. Are a smoker
•4. Are pregnant
•5. Have a history of any circadian or sleep disorder as confirmed by pre-study questionnaires
•6. Have habitual irregular sleep patterns on more than 2 nights per week (bed time outside 22:00-1:00 h and wake up time outside 6:00-9:00 h) or a sleep duration on more than 2 nights per week < 7 or > 9 hours
•7. Have donated over 400 ml of blood in the three months preceding the study
•8. Exceed the defined criteria of pre-study questionnaires:
•8.1. BMI: < 25kg/m2
•8.2. 30 = Horne-Östberg questionnaire =70
•8.3. Pittsburgh Sleep Quality Index: > 5
•8.4. Epworth Sleepiness Scale > 9
•9. Have travelled across more than two time zones within a month before or during the study
•10. Are currently taking part in a clinical trial or another research study or have taken part within the last 3 months
•11. Have participated in rotating or night shift work for more than 6 months prior to or during the study

发起方

niversity of Surrey