18F-Choline PET/CT for patients with primary hyperparathyroidism and negative SPECT/CT

Completed

• Conditions: primary hyperparathyroidism; overproduction Parathyroid Hormone; 10033949

• Registration Number: NL-OMON40137
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

- Patients who have signed informed consent;- Age >= 18 years;- Biochemically proven PHP;- Indication for surgery;- Negative SPECT/CT

Exclusion Criteria

- Pregnancy ;- Patients with MEN syndrome

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main outcome of the study is the performance of FCH PET/CT in localizing<br /><br>the pathological parathyroid gland(s) defined as PPV and sensitivity. This will<br /><br>be controlled by surgically removing the suspicious gland(s). If post-operative<br /><br>normalisation of the ICa level is found, surgery is considered successful.<br /><br>Therefore the endpoint of our study will be a normal blood hormone level of ICa<br /><br>one week after surgery.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>NA</p><br>