Nutritional Supplementation of Flavonoids Quercetin and Curcumin for Early Mild Symptoms of COVID-19
- Conditions
- COVID-19
- Interventions
- Drug: Standard of careDietary Supplement: Investigational treatment
- Registration Number
- NCT05130671
- Lead Sponsor
- King Edward Medical University
- Brief Summary
The purpose of this study is to investigate the therapeutic benefits of flavonoids nutritional supplements quercetin and curcumin for early mild symptoms of COVID-19.
- Detailed Description
Flavonoids nutritional supplements quercetin and curcumin have demonstrated strong antioxidant, broad-spectrum anti-viral and anti-inflammatory properties including against the respiratory tract infections. They are widely used to boost the immunity against infections and keeping healthy life-style. Results from recent published studies have shown positive results for quercetin and curcumin in patients with COVID-19.
In the present study the investigators aim to study the combined beneficial effects of quercetin and curcumin in addition to standard of care for managing early mild symptoms of COVID-19 in community-based patients.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
- Patients must be 18 years of age or older, of either gender
- Patients must be tested positive for SARS-CoV-2 by RT-PCR
- Patients must exhibit typical symptoms of COVID-19 disease at screening such as fever, fatigue, a dry and contagious cough, loss of appetite, body aches, shortness of breath, mucus or phlegm, sore throat, headache, chills, sometimes withshaking, loss of smell or taste, congestion or runny nose, nausea, or vomiting, diarrhea, muscular pain etc.
- Patients must be in the early stage of COVID-19 disease who do not require hospitalization at the time of screening
- Patients must be under the care of a Physician for diagnosis of COVID-19
- Patients who have signed informed consent
- Patients with proven hypersensitivity or allergic reaction to quercetin or curcumin
- Patients with known chronic kidney disease with estimated creatinine clearance < 50 mL/minute or need for dialysis
- Patients who are severely hypotensive defined as needing hemodynamic pressors to maintain blood pressure
- Patients taking anticoagulant/antiplatelet drugs such as Coumarine, Heparine, Aspirin, Clopidrogel, dalteparin, enoxaparin, ticlopidine and warparin.
- Patients with gallstone obstruction
- Hypothyroid suppering patients
- Patients with moderate or severe thrombocytopenia (platelet count <100 ×10⁹/L);
- Pregnant patients
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Standard of care Standard of care This arm will receive the standard of care as per the hospital guidelines. Investigational treatment Standard of care This arm will receive combination of nutritional supplements quercetin and curcumin as add-on to the standard of care. Investigational treatment Investigational treatment This arm will receive combination of nutritional supplements quercetin and curcumin as add-on to the standard of care.
- Primary Outcome Measures
Name Time Method Testing negative for SARS-CoV-2 by Reverse Transcription Polymerase Chain Reaction (RT-PCR) Day 7 Testing of naso-pharyngeal swab for COVID-19
COVID-19 symptoms improvement Day 7 Improvement of the typical symptoms associated with COVID-19 infection
- Secondary Outcome Measures
Name Time Method Improvement in CRP level Day 7 Improvement in the CRP levels
Improvement in D-dimers level Day 7 Improvement in D-dimers level
Improvement in LDH levels Day 7 Improvement in LDH levels
Improvement in ferritin levels Day 7 Improvement in Ferritin levels
Improvement in full blood count (CBC) Day 7 Improvement in CBC levels
Trial Locations
- Locations (1)
King Edward Medical University Teaching Hospital
🇵🇰Lahore, Punjab, Pakistan