Study Comparing Veliparib Plus Carboplatin and Paclitaxel Versus Placebo Plus Carboplatin and Paclitaxel in Previously Untreated Advanced or Metastatic Squamous Non-Small Cell Lung Cancer
- Conditions
- Squamous Non-Small Cell Lung Cancer
- Interventions
- Registration Number
- NCT02106546
- Lead Sponsor
- AbbVie
- Brief Summary
The purpose of this study is to evaluate the safety and efficacy of the addition of veliparib plus carboplatin and paclitaxel versus the addition of placebo plus carboplatin and paclitaxel in adults with advanced or metastatic squamous non-small cell lung cancer (NSCLC).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 970
- Life expectancy > 12 weeks
- Subject must have cytologically or histologically confirmed squamous NSCLC.
- Subject must have advanced or metastatic squamous NSCLC that is not amenable to surgical resection or radiation with curative intent at time of study Screening.
- Subjects with recurrent squamous NSCLC after surgical treatment that is not amenable to surgical resection or radiation with curative intent are eligible.
- Subject must have at least 1 unidimensional measurable NSCLC lesion on a computerized tomography (CT) scan as defined by Response Evaluation Criteria In Solid Tumors (RECIST - version 1.1).
- Subject has a known hypersensitivity to paclitaxel or to other drugs formulated with polyethoxylated castor oil (Cremophor).
- Subject has a known hypersensitivity to platinum compounds.
- Subject has peripheral neuropathy >= grade 2.
- Subject has non-squamous NSCLC, or a known epidermal growth factor receptor (EGFR) mutation of exon 19 deletion or L858R mutation in exon 21, or a known anaplastic lymphoma kinase (ALK) gene rearrangement.
- Subject has received prior cytotoxic chemotherapy (including definitive chemoradiotherapy) for NSCLC, except for adjuvant or neoadjuvant therapy.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo + Carboplatin + Paclitaxel Placebo to veliparib Participants received placebo orally BID on Days -2 to 5 (7 consecutive days) of each 21-day cycle and carboplatin at an AUC 6 mg/mL/min and paclitaxel 200 mg/m² by IV infusion on Day 1 of each 21-day cycle for up to a maximum 6 cycles of treatment, until treatment toxicity which, in the Investigator's opinion, prohibited further therapy, or until radiographic progression. Veliparib + Carboplatin + Paclitaxel Carboplatin Participants received veliparib 120 mg orally twice daily (BID) on Days -2 to 5 (7 consecutive days) of each 21-day cycle and carboplatin at an area under the concentration-time curve (AUC) 6 mg/mL/min and paclitaxel 200 mg/m² by intravenous (IV) infusion on Day 1 of each 21-day cycle for up to a maximum 6 cycles of treatment, until treatment toxicity which, in the Investigator's opinion, prohibited further therapy, or until radiographic progression. Veliparib + Carboplatin + Paclitaxel Veliparib Participants received veliparib 120 mg orally twice daily (BID) on Days -2 to 5 (7 consecutive days) of each 21-day cycle and carboplatin at an area under the concentration-time curve (AUC) 6 mg/mL/min and paclitaxel 200 mg/m² by intravenous (IV) infusion on Day 1 of each 21-day cycle for up to a maximum 6 cycles of treatment, until treatment toxicity which, in the Investigator's opinion, prohibited further therapy, or until radiographic progression. Veliparib + Carboplatin + Paclitaxel Paclitaxel Participants received veliparib 120 mg orally twice daily (BID) on Days -2 to 5 (7 consecutive days) of each 21-day cycle and carboplatin at an area under the concentration-time curve (AUC) 6 mg/mL/min and paclitaxel 200 mg/m² by intravenous (IV) infusion on Day 1 of each 21-day cycle for up to a maximum 6 cycles of treatment, until treatment toxicity which, in the Investigator's opinion, prohibited further therapy, or until radiographic progression. Placebo + Carboplatin + Paclitaxel Carboplatin Participants received placebo orally BID on Days -2 to 5 (7 consecutive days) of each 21-day cycle and carboplatin at an AUC 6 mg/mL/min and paclitaxel 200 mg/m² by IV infusion on Day 1 of each 21-day cycle for up to a maximum 6 cycles of treatment, until treatment toxicity which, in the Investigator's opinion, prohibited further therapy, or until radiographic progression. Placebo + Carboplatin + Paclitaxel Paclitaxel Participants received placebo orally BID on Days -2 to 5 (7 consecutive days) of each 21-day cycle and carboplatin at an AUC 6 mg/mL/min and paclitaxel 200 mg/m² by IV infusion on Day 1 of each 21-day cycle for up to a maximum 6 cycles of treatment, until treatment toxicity which, in the Investigator's opinion, prohibited further therapy, or until radiographic progression.
- Primary Outcome Measures
Name Time Method Overall Survival (OS) in current smokers Up to 3 years from first dose of study drug Time to death for a given subject will be defined as the number of days from the date that the subject was randomized to the date of the subject's death.
- Secondary Outcome Measures
Name Time Method Progressive-Free Survival (PFS) in current smokers and in all subjects Up to 3 years from first dose of study drug Defined as the number of days from the date that the subject was randomized to the date the subject experiences an event of disease progression or to the date of death (all causes of mortality) if disease progression is not reached.
Objective Response Rate (ORR) in current smokers and in all subjects Up to 3 years from first dose of study drug Objective response rate is defined as the proportion of subjects with complete or partial response as determined by the investigator per RECIST (version 1.1)
Overall Survival (OS) in all subjects Up to 3 years from first dose of study drug Time to death for a given subject will be defined as the number of days from the date that the subject was randomized to the date of the subject's death.
Trial Locations
- Locations (225)
Winship Cancer Institute of Emory University /ID# 124061
🇺🇸Atlanta, Georgia, United States
Parkland Health and Hosp Syste /ID# 128518
🇺🇸Dallas, Texas, United States
Texas Oncology- Baylor Charles A. Sammons Cancer Center /ID# 128385
🇺🇸Dallas, Texas, United States
Franciscan St. Francis Health /ID# 126678
🇺🇸Indianapolis, Indiana, United States
Nebraska Hematology Oncology /ID# 127699
🇺🇸Lincoln, Nebraska, United States
Ordensklinikum Linz GmbH, Elisabethinen /ID# 126183
🇦🇹Linz, Austria
State Institution Republican Scientific Practical Center of Oncology and Medica /ID# 125815
🇧🇾Lesnoy, Belarus
Princess Margaret Cancer Centre /ID# 126155
🇨🇦Toronto, Ontario, Canada
CSSS Alphonse-Desjardins, CHAU de Levis /ID# 126149
🇨🇦Quebec City, Quebec, Canada
Dartmouth-Hitchcock Medical Center /ID# 128075
🇺🇸Lebanon, New Hampshire, United States
Cross Cancer Institute /ID# 126154
🇨🇦Edmonton, Alberta, Canada
North Estonian Medical Centre /ID# 128215
🇪🇪Tallinn, Estonia
Vaasa Central Hospital /ID# 125896
🇫🇮Vaasa, Finland
Hopital Haut-Lévêque /ID# 135270
🇫🇷Pessac CEDEX, Gironde, France
Klinikum Kassel /ID# 127025
🇩🇪Kassel, Germany
University General Hospital of Heraklion PA.G.N.I /ID# 125877
🇬🇷Heraklion, Greece
Bekes Megyei Pandy Kalman Korhaz /ID# 126117
🇭🇺Gyula, Hungary
The Ottawa Hospital /ID# 126522
🇨🇦Ottawa, Ontario, Canada
The Jones Clinic, PC /ID# 124062
🇺🇸Germantown, Tennessee, United States
Juravinski Cancer Clinic /ID# 126153
🇨🇦Hamilton, Ontario, Canada
Naser Institute for Res & Dev /ID# 129263
🇪🇬Cairo, Egypt
Hopital Larrey - CHU de Toulouse /ID# 128394
🇫🇷Toulouse, France
Centre Antoine Lacassagne /ID# 126360
🇫🇷Nice, France
Univ Johannes Gutenberg /ID# 125603
🇩🇪Mainz, Germany
Hospital Angeles Centro Medico /ID# 127620
🇲🇽San Luis Potosí, Mexico
Catharina Ziekenhuis /ID# 125577
🇳🇱Eindhoven, Netherlands
Jeroen Bosch Ziekenhuis /ID# 125709
🇳🇱S Hertogenbosch, Netherlands
Isala /ID# 125579
🇳🇱Zwolle, Netherlands
University Hospital Bezanijska /ID# 128761
🇷🇸Belgrade, Serbia
University of Vermont Medical Center /ID# 128064
🇺🇸Burlington, Vermont, United States
The Queen Elizabeth Hospital /ID# 125607
🇦🇺Woodville, South Australia, Australia
Klinicki bolnicki centar Osijek /ID# 132214
🇭🇷Osijek, Osjecko-baranjska Zupanija, Croatia
CHU Hopital Nord /ID# 128388
🇫🇷Marseille, Bouches-du-Rhone, France
Centre Hosp Intercommunal de Creteil /ID# 125922
🇫🇷Creteil, Val-de-Marne, France
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 125879
🇬🇷Athens, Greece
Debreceni Egyetem Klinikai Központ /ID# 126119
🇭🇺Debrecen, Hungary
Veszprem Megyei Tudogyogyintez /ID# 126121
🇭🇺Farkasgyepu, Hungary
Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz /ID# 126120
🇭🇺Szolnok, Hungary
University Hospital Waterford /ID# 126178
🇮🇪Waterford, Ireland
A.O.U. San Luigi Gonzaga /ID# 125700
🇮🇹Orbassano, Italy
National Cancer Institute /ID# 126323
🇱🇹Vilnius, Lithuania
NZOZ Magodent Ctr. Med. Ostro /ID# 126545
🇵🇱Warsaw, Poland
Institute for Oncology and Rad /ID# 128721
🇷🇸Belgrade, Serbia
Flinders Centre for Innovation /ID# 125605
🇦🇺Bedford Park, South Australia, Australia
Charite-Univ. Berlin, Benjamin-Franklin /ID# 125708
🇩🇪Berlin, Germany
GVI Oncology /ID# 126102
🇿🇦Port Elizabeth, Eastern Cape, South Africa
CHRU Lille - Hôpital Claude Huriez /ID# 126353
🇫🇷Lille CEDEX, Hauts-de-France, France
Clinica de Neoplasias Litoral - Centro de Novos Tratamentos Itajai /ID# 127738
🇧🇷Itajai, Santa Catarina, Brazil
Fundacao Antonio Prudente - AC Camargo Cancer Center /ID# 126737
🇧🇷Sao Paulo, Brazil
McGill Univ HC /ID# 130431
🇨🇦Montreal, Quebec, Canada
Centre Hospitalier Le Mans /ID# 127902
🇫🇷Le Mans CEDEX 9, Sarthe, France
Orszagos Koranyi Pulmonologiai Intezet /ID# 126112
🇭🇺Budapest XII, Budapest, Hungary
Matrahaza Gyogyintezet /ID# 126109
🇭🇺Kékesteto, Hungary
Assaf Harofeh Medical Center /ID# 127076
🇮🇱Be'er Ya'akov, Israel
Amphia Ziekenhuis /ID# 126466
🇳🇱Breda, Netherlands
Atrium-Orbis Zuyderland Medisch Centrum /ID# 125710
🇳🇱Heerlen, Netherlands
Nordland Hospital /ID# 126337
🇳🇴Bodø, Norway
Sorlandet Sykehus HF /ID# 126341
🇳🇴Kristiansand, Norway
Netcare Oncology Intervent Ctr /ID# 126100
🇿🇦Cape Town, Western Cape, South Africa
Mrukmed. Lekarz Beata Madej Mruk i Partner /ID# 126548
🇵🇱Rzeszów, Podkarpackie, Poland
Hirslanden Medical Center /ID# 128216
🇨🇭Aarau, Switzerland
Marmara University Medical Fac /ID# 126187
🇹🇷Istanbul, Turkey
University of Calgary /Id# 126326
🇨🇦Calgary, Alberta, Canada
Iucpq-Ul /Id# 126524
🇨🇦Québec, Quebec, Canada
Tartu University Hospital /ID# 127735
🇪🇪Tartu, Estonia
CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 135234
🇭🇺Miskolc, Borsod-Abauj-Zemplen, Hungary
Hadassah University Hospital /ID# 127077
🇮🇱Jerusalem, Israel
Vrije Universiteit Medisch Centrum /ID# 125578
🇳🇱Amsterdam, Netherlands
Sykehuset i Vestfold HF /ID# 126340
🇳🇴Tonsberg, Norway
Szpital Morski im. PCK /ID# 126547
🇵🇱Gdynia, Poland
Sverdlovsk Regional Oncology Center Dispensary /ID# 128457
🇷🇺Ekaterinburg, Sverdlovskaya Oblast, Russian Federation
Hospital Duran i Reynals /ID# 125161
🇪🇸L'Hospitalet de Llobregat, Barcelona, Spain
Inselspital, Universitaetsklinik /ID# 126347
🇨🇭Bern, Switzerland
Spital STS AG /ID# 126348
🇨🇭Thun, Switzerland
Fejer Megyei Szent Gyorgy Korh /ID# 126118
🇭🇺Szekesfehervar, Hungary
Istituto Oncologico del Medite /ID# 132844
🇮🇹Viagrande, Italy
Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 127176
🇱🇹Kovno, Kaunas, Lithuania
Centro Estatal de Cancerologia /ID# 127583
🇲🇽Chihuahua, Mexico
Haukeland University Hospital /ID# 126338
🇳🇴Bergen, Hordaland, Norway
Oslo Universitetssykehus, Radiumhospitalet /ID# 126335
🇳🇴Oslo, Norway
Belgorod Oncology Dispensary /ID# 129899
🇷🇺Belgorod, Russian Federation
Clinical Center of Nis /ID# 128735
🇷🇸NIS, Nisavski Okrug, Serbia
Kantonsspital St. Gallen /ID# 126349
🇨🇭St. Gallen, Sankt Gallen, Switzerland
Institute For Pulmonary Diseas /ID# 128737
🇷🇸Sremska Kamenica, Serbia
Cheltenham General Hospital /ID# 125692
🇬🇧Cheltenham, Gloucestershire, United Kingdom
Ege University Medical Faculty /ID# 126189
🇹🇷Izmir, Turkey
Municipal Non-Profit Enterprise City Clinical Hospital No.4 of Dnipro City Counc /ID# 128217
🇺🇦Dnipro, Ukraine
Municipal Non-Profit Enterprise of Sumy Regional Council Sumy Regional Clinical /ID# 128219
🇺🇦Sumy, Ukraine
Norfolk and Norwich Univ Hosp /ID# 125697
🇬🇧Norwich, Norfolk, United Kingdom
Henry Ford Health System /ID# 126500
🇺🇸Detroit, Michigan, United States
Minnesota Oncology Hematology, PA /ID# 127473
🇺🇸Minneapolis, Minnesota, United States
Dr Albert, Bouwer and Jordaan Incorporated /ID# 126098
🇿🇦Pretoria, Gauteng, South Africa
Hospital Universitario HM Sanchinarro /ID# 125162
🇪🇸Madrid, Spain
Gavle Sjukhus /ID# 126444
🇸🇪Gavle, Sweden
Hospital Universitario Puerta de Hierro Majadahonda /ID# 125160
🇪🇸Majadahonda, Madrid, Spain
Akdeniz University Medical Fac /ID# 126997
🇹🇷Antalya, Turkey
Dr. Suat Seren Gogus Has /ID# 126190
🇹🇷Izmir, Turkey
Poltava Regional Clinical Oncology Centre of Poltava Regional Council /ID# 128223
🇺🇦Poltava, Ukraine
Communal non-profit enterprise Regional Center of Oncology /ID# 128221
🇺🇦Kharkiv, Kharkivska Oblast, Ukraine
Gartnavel General Hospital /ID# 126233
🇬🇧Glasgow, United Kingdom
Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 126186
🇹🇷Istanbul, Turkey
Cherkassy Regional Onc Ctr /ID# 128222
🇺🇦Cherkasy, Ukraine
Regional Municipal Non-Profit Enterprise Bukovynian Clinical Oncology Center /ID# 128220
🇺🇦Chernivtsi, Ukraine
Lviv Oncological Regional Therapeutical and Diagnostic Centre /ID# 128218
🇺🇦Lviv, Ukraine
Betsi Cadwaladr Univ Health Bo /ID# 127177
🇬🇧Bangor, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust Freeman Hospital /ID# 129228
🇬🇧Newcastle Upon Tyne, United Kingdom
The Clatterbridge Cancer Ctr /ID# 125695
🇬🇧Wirral, United Kingdom
LA Hem-Oncology Med Group /ID# 129178
🇺🇸Los Angeles, California, United States
Holy Cross Hospital /ID# 128074
🇺🇸Fort Lauderdale, Florida, United States
St. Luke's Mountain States Tumor Institute - Boise /ID# 124059
🇺🇸Boise, Idaho, United States
Northeast Arkansas Clinical Ch /ID# 128071
🇺🇸Jonesboro, Arkansas, United States
Illinois Cancer Specialists /ID# 127468
🇺🇸Arlington Heights, Illinois, United States
Cancer Specialists of North Florida - Southpoint /ID# 127815
🇺🇸Jacksonville, Florida, United States
Midwestern Regional CTC /ID# 126124
🇺🇸Zion, Illinois, United States
SE Nebraska Hema/Oncology Consultants P.C.d/b/a Southeast Nebraska Cancer Center /ID# 126477
🇺🇸Lincoln, Nebraska, United States
NorthShore University HealthSystem - Evanston Hospital /ID# 128585
🇺🇸Evanston, Illinois, United States
Texas Oncology - Paris /ID# 127484
🇺🇸Paris, Texas, United States
Opca bolnica Pula /ID# 126540
🇭🇷Pula, Croatia
Nemocnice Kyjov, prispevkova organizace /ID# 125819
🇨🇿Kyjov, Czechia
University of Texas MD Anderson Cancer Center /ID# 127946
🇺🇸Houston, Texas, United States
Comprehensive Cancer Ctrs Neva /ID# 127491
🇺🇸Las Vegas, Nevada, United States
UT Southwestern Medical Center /ID# 127876
🇺🇸Dallas, Texas, United States
Sparrow Regional Cancer Center, Sparrow Health System /ID# 127156
🇺🇸Lansing, Michigan, United States
Hackensack Univ Med Ctr /ID# 124057
🇺🇸Hackensack, New Jersey, United States
Brest Regional Hospital /ID# 125955
🇧🇾Brest, Belarus
Texas Oncology - Waco /ID# 127459
🇺🇸Waco, Texas, United States
Instituto Nacional de Câncer José de Alencar Gomes da Silva (INCA) /ID# 127309
🇧🇷Rio de Janeiro, Brazil
Northwest Cancer Specialists, P.C. /ID# 127486
🇺🇸Vancouver, Washington, United States
Sunshine Coast University Hosp /ID# 125608
🇦🇺Birtinya, Queensland, Australia
The Townsville Hospital /ID# 125609
🇦🇺Douglas, Queensland, Australia
Bobruysk Interdistrict Onco. /ID# 128999
🇧🇾Bobruisk, Belarus
Barwon Health University Hospital Geelong /ID# 125606
🇦🇺Geelong, Victoria, Australia
Mogilev Reg Clin Oncology Dis /ID# 128639
🇧🇾Mogilev, Belarus
Vitebsk Reg Clin Onc Disp /ID# 125516
🇧🇾Vitebsk, Belarus
Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 126736
🇧🇷Barretos, Sao Paulo, Brazil
Instituto COI de Educacao e Pesquisa /ID# 127739
🇧🇷Rio de Janeiro, Brazil
Klinika za plucne bolesti Jordanovac /ID# 126537
🇭🇷Zagreb, Grad Zagreb, Croatia
Herlev Hospital /ID# 125995
🇩🇰Herlev, Hovedstaden, Denmark
Odense Universitets Hospital /ID# 125996
🇩🇰Odense C, Syddanmark, Denmark
Fakultni Nemocnice Olomouc /ID# 125820
🇨🇿Olomouc, Olomoucky Kraj, Czechia
Nemocnice Na Plesi s.r.o. /ID# 125817
🇨🇿Nová Ves pod Pleší, Pribram, Czechia
Hospital Pontchaillou /ID# 126356
🇫🇷Rennes, France
Klinik Loewenstein GmbH /ID# 126191
🇩🇪Löwenstein, Germany
Papageorgiou General Hospital Thessaloniki /ID# 125876
🇬🇷Nea Efkarpia, Thessaloniki, Greece
Metropolitan Hospital /ID# 125878
🇬🇷Athens, Greece
Petz Aladar Megyei Oktato Korh /ID# 126110
🇭🇺Gyor, Hungary
Cairo Uni Hosp Al Kasr El Ainy /ID# 128338
🇪🇬Cairo, Egypt
Opca bolnica Dr. Josip Bencevi /ID# 126539
🇭🇷Slavonski Brod, Croatia
Helsinki Univ Central Hospital /ID# 125897
🇫🇮Helsinki, Finland
CHRU de Brest - Hopital Morvan /ID# 127903
🇫🇷Brest, France
Lungen Clinic Grosshansdorf /ID# 126107
🇩🇪Grosshansdorf, Germany
Cairo Uni Hosp Al Kasr El Ainy /ID# 128340
🇪🇬Cairo, Egypt
Azienda Ospedaliera-Universitaria di Perugia-Divisione di Oncologia Medica. /ID# 125699
🇮🇹Perugia, Italy
St. James's Hospital /ID# 126177
🇮🇪Dublin 8, Dublin, Ireland
Tudogyogyintezet Toeroekbalint /ID# 126111
🇭🇺Torokbalint, Hungary
Cork University Hospital /ID# 126176
🇮🇪Cork, Ireland
Beaumont Hospital /ID# 126218
🇮🇪Dublin, Ireland
University Hospital Limerick /ID# 126175
🇮🇪Limerick, Ireland
Riga East Clinical Univ Hosp /ID# 125597
🇱🇻Riga, Latvia
Istituto Europeo di Oncologia /ID# 125702
🇮🇹Milan, Italy
Azienda Ospedaliera San Gerardo di Monza _ Oncologia Medica /ID# 125704
🇮🇹Monza, Italy
Azienda Ospedaliero Uni Parma /ID# 125703
🇮🇹Parma, Italy
Meir Medical Center /ID# 127078
🇮🇱Kfar Saba, Israel
Sheba Medical Center /ID# 127079
🇮🇱Ramat Gan, Israel
AO San Giuseppe Moscati /ID# 125701
🇮🇹Avellino, Italy
P. Stradins Clinical Univ Hosp /ID# 126322
🇱🇻Riga, Latvia
Cancerologia de Queretaro S.C. /ID# 125920
🇲🇽Santiago de Querétaro, Mexico
Wellington Hospital (Capital and Coast District Health Board) /ID# 125755
🇳🇿Wellington, New Zealand
Stavanger University Hospital /ID# 126336
🇳🇴Stavanger, Norway
The Oncology Centre /ID# 126096
🇿🇦Durban, Kwazulu-Natal, South Africa
Karolinska Univ Sjukhuset /ID# 126445
🇸🇪Solna, Sweden
Fundacion Instituto Valenciano Oncologia IVO /ID# 125205
🇪🇸Valencia, Spain
Mazowiecki Szpital Onkologiczn /ID# 126546
🇵🇱Wieliszew, Poland
State Budgetary Healthcare Institution"Irkutsk Regional Oncology Center /ID# 128460
🇷🇺Irkutsk, Russian Federation
Orenburg Regional Clinical Onc /ID# 137474
🇷🇺Orenburg, Russian Federation
CCA Braga - Hospital de Braga /ID# 125837
🇵🇹Braga, Portugal
Ctr Hosp Univ Coimbra, EPE /ID# 125838
🇵🇹Coimbra, Portugal
Hospital Pulido Valente /ID# 125835
🇵🇹Lisbon, Portugal
IPO Porto FG, EPE /ID# 125836
🇵🇹Porto, Portugal
Volgograd Regional Clinical Oncology Dispensary /ID# 126350
🇷🇺Volgograd, Volgogradskaya Oblast, Russian Federation
Ogarev Mordovia State Univ /ID# 127595
🇷🇺Saransk, Russian Federation
Smolensk Regional Onc Clin Dis /ID# 127144
🇷🇺Smolensk, Russian Federation
Centro Hospitalar de Sao Joao, EPE /ID# 125875
🇵🇹Porto, Portugal
VA Caribbean Healthcare System /ID# 124562
🇵🇷San Juan, Puerto Rico
Clinical Center Serbia /ID# 128738
🇷🇸Belgrade, Beograd, Serbia
Sahlgrenska University Hosp /ID# 129997
🇸🇪Goteborg, Sweden
State Regional Budgetary Healthcare Institution " Murmansk Regional Oncology Dis /ID# 128461
🇷🇺Murmansk, Russian Federation
Cancer Research Institute Siberian Branch of the Russian Academy of Medical Scie /ID# 127143
🇷🇺Tomsk, Russian Federation
MEDEON, s.r.o. /ID# 128517
🇸🇰Pieštany, Slovakia
Wits Clinical Research Site /ID# 126101
🇿🇦Johannesburg, Gauteng, South Africa
Hospital Universitario Vall d'Hebron /ID# 125159
🇪🇸Barcelona, Spain
Sandton Oncology Centre /ID# 126097
🇿🇦Johannesburg, Gauteng, South Africa
Univerzitna Nemocnica Bratislava /ID# 126342
🇸🇰Bratislava, Slovakia
University of Pretoria /ID# 127297
🇿🇦Pretoria, Gauteng, South Africa
University Hospital Linkoping /ID# 126443
🇸🇪Linkoping, Sweden
James Paget University Hosp /ID# 125696
🇬🇧Great Yarmouth, United Kingdom
Cancercare Outeniqua Oncology Unit /ID# 126103
🇿🇦George, Western Cape, South Africa
The Royal Bournemouth Hospital /ID# 125690
🇬🇧Bournemouth, United Kingdom
Guy's and St Thomas' NHS Found /ID# 125694
🇬🇧London, London, City Of, United Kingdom
North Devon District Hospital /ID# 125689
🇬🇧Barnstaple, United Kingdom
East Kent Hosp Univ NHS Trust /ID# 125698
🇬🇧Canterbury, United Kingdom
Maidstone Hospital /ID# 125693
🇬🇧Maidstone, United Kingdom
Charing Cross Hospital /ID# 125688
🇬🇧London, United Kingdom
Mary Potter Oncology Centre /ID# 126099
🇿🇦Pretoria, Gauteng, South Africa
Ingalls Memorial Hosp /ID# 128360
🇺🇸Harvey, Illinois, United States
Appalachian Regional Healthcare, Inc (ARH) /ID# 128061
🇺🇸Hazard, Kentucky, United States
Virginia Oncology Associates /ID# 127458
🇺🇸Norfolk, Virginia, United States
Northwest Cancer Specialists, P.C. /ID# 127488
🇺🇸Vancouver, Washington, United States
Vitkovicka nemocnice a. s. /ID# 127023
🇨🇿Ostrava, Czechia
Gabrail Cancer Center Research /ID# 127415
🇺🇸Canton, Ohio, United States
Goshen Center for Cancer Care /ID# 123875
🇺🇸Goshen, Indiana, United States
Penn State University and Milton S. Hershey Medical Center /ID# 126676
🇺🇸Hershey, Pennsylvania, United States
Hospital Sao Lucas da PUCRS /ID# 127737
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Southern Medical Day Care Ctr /ID# 125604
🇦🇺Wollongong, New South Wales, Australia
Nemocnice Novy Jicin /ID# 125818
🇨🇿Nový Jičín 1, Czechia
University of Alexandria /ID# 128337
🇪🇬Alexandria, Egypt
Ziekenhuis St. Jansdal /ID# 125576
🇳🇱Harderwijk, Netherlands
Hospital Senhora da Oliveira de Guimaraes, EPE /ID# 126761
🇵🇹Guimaraes, Braga, Portugal
Federal State Budgetary Scientific Institution N.N. Blokhin Russian Cancer Resea /ID# 128458
🇷🇺Moscow, Moskva, Russian Federation
Hospital Universitario Virgen del Rocio /ID# 125207
🇪🇸Sevilla, Spain
Texas Oncology - Austin Midtown /ID# 127477
🇺🇸Austin, Texas, United States
Texas Oncology - South Austin /ID# 127476
🇺🇸Austin, Texas, United States
VA Eastern Colorado Healthcare System /ID# 128065
🇺🇸Aurora, Colorado, United States
University of Florida - Archer /ID# 126476
🇺🇸Gainesville, Florida, United States
Victoria Hospital /ID# 126669
🇨🇦London, Ontario, Canada
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