Optimal Management of HIV-Infected Adults at Risk for Kidney Complications in Nigeria

Vanderbilt University Medical Center0 个研究点目标入组 280 人开始时间: 2017年11月27日最近更新: 2023年5月29日

适应症

试验速览

暂无简介。

•Adult (18-70 years of age)
•Documented positive HIV-1 ELISA
•On ART for a minimum of 6 months, suppresses plasma viral load result (<20 copies/mL) with past six months
•Average uACR between 30-300 mg/g (based on 2 uACRs [first morning voids], with the second obtained 4-8 weeks after first specimen)
•Urine dipstick proteinuria analysis result <2.0
•eGFR = > 60ml/min/1.73m2 (using CKD-EPI-Cr-CYC equation)
•If female, non pregnant (documentation of negative urine pregnancy test ) and not breastfeeding/lactating

•K+ >5.0 meEq/L or reasons to be concerned about hyperkalemia
•Known history of diabetes mellitus (would qualify for treatment with an ACEi/ARB)
•Poorly controlled hypertension (=3 BP readings >160/110 in past 6 months)
•Known history of congestive heart failure (chronic)
•Average uACR (calculated on values obtained from 2 successive measures 4-8 weeks apart) of < 30 mg/g OR > 300 mg/g
•Relative symptomatic hypotension (BP <90/60)
•Currently receiving an ACEi and/or ARB;
•Lack of suitability as a study candidate (i.e. active substance use disorder, active use of potentially nephrotoxic medication(s) (i.e. traditional medicines, etc.) and/or history of poor compliance (i.e. multiple missed scheduled clinic appointments, etc.)

发起方