NL-OMON44250已完成不适用
Randomized controlled trial comparing conVEntional RadioTherapy with stereotactIC body radiotherapy in patients with spinAL metastases - VERTICAL study
niversitair Medisch Centrum Utrecht0 个研究点目标入组 110 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 110
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Radiographic evidence of bone metastases;
- •Per spinal lesion no more than 3 consecutive spine segments involved with one unaffected vertebral body above and below;
- •No more than 2 painful lesions needing treatment;
- •Histologic proof of malignancy;
- •No compression of spinal cord;
- •No or mild neurological signs (i.e. radiculopathy, dermatomal sensory change, and muscle strength of involved extremity is Medical Research Counsil (MRC) 4/5);
- •Medically inoperable or patient refused surgery;
- •Karnofsky performance score (KPS) * 50;
- •Numeric rating scale (NRS) * 3;
- •Age * 18 years;
- •Written informed consent;
- •Filling out PRESENT-questionnaires.
排除标准
- •General exclusion criteria:
- •Radiosensitive histology such as multiple myeloma, lymphoma, small cell and germ cell;
- •MRI cannot be completed for any reason (in according with the MRI protocol of the Department of Radiology);
- •Impossible to delineate metastasis and organs at risk (OAR) due to artefacts on CT or MRI from previous surgical stabilisation;
- •Unable to undergo SBRT treatment, according to treating doctor*s opinion;
- •Severe, worsening or progressive neurological deficit;
- •Unstable bone requiring surgical stabilization;
- •Patient with < 3 months life expectancy;
- •Previous EBRT or SBRT to same location with bone metastases as target volume;
- •Chemotherapy or systemic radionuclide delivery within 24 hours before and after SBRT;
- •Patients with oligometastases who are selected for SBRT after multidisciplinary consultation;
- •Maximum diameter of target volume > 10 cm;
- •Extension of the tumour to the skin. ;Spinal metastases specific exclusion criteria:
- •Lesion in C1 and C2;
- •Epidural disease.;Specific exclusion criteria for bone metastases in the extremities:
- •Fixation material in target volume;
- •Impending fracture (if surgery or stabilisation is an option).
研究者
相似试验
暂停
不适用
Best timing of a cesarean section in non-progressing labouron-progressing labour (niet vorderende ontsluiting)Diagnosis (diagnose)Cesarean section (keizersnede)Morbidity (morbiditeit)NL-OMON26046Maastricht University Medical Centre +NVOG Consortium 2.02,388
已完成
2 期
Comparing the effectiveness of Mindfulness based stress reduction and Cognitive behavioral therapy on anger, perceived stress and quality of life and blood pressure in cardiac patientsCondition 1: Heart Disease. Condition 2: Anger. Condition 3: Perceived Stress.For morbidity, duration as used in categories I21, I22,I24 and I25 refer to the interval elapsing between onset of the ischaemic episode and admission to care. For mortality, duration refers to the interval elapsing between onset and death.I20,I21,I2IRCT2015012520794N1Vice chancellor for research of Kashan University of Medical Sciences and Health Services60
已完成
不适用
Randomized controlled trial comparing the simplified and standard regimen for focal radiofrequency ablatiodysplasia in Barrett's esophagusdysplastic Barrett mucosa10017990NL-OMON42316Academisch Medisch Centrum60
招募中
不适用
Simplified focal ablation RCTBarrett's esophagus / Barrett slijmvlies dysplasia in Barrett's esophagus / onrustige cellen in het Barrett slijmvliesRadiofrequency ablation / radiofrequente ablatieRFANL-OMON29446Academisch Medisch Centrum Amsterdam72
已完成
1 期
Study comparing the effect of pain relief provided by one combination of drug(Ketofol) with that of the other(Etofen)CTRI/2019/01/017329Department of Emergency Medicine Bangalore Baptist Hospital Bellary road Hebbal Bangalore108