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Autologous Endometrial Coculture (AECCT)

Not Applicable
Terminated
Conditions
Infertility
Interventions
Procedure: AECC (Autologous endometrial coculture)
Other: no endometrial biopsy or Autologous endometrial coculture (AECC) performed
Registration Number
NCT01472861
Lead Sponsor
Weill Medical College of Cornell University
Brief Summary

The purpose of this study is to determine if the use of Autologous Endometrial Coculture (AECC) in young in vitro fertilization (IVF) patients with poor ovarian reserve improves pregnancy outcome.

Detailed Description

Young women with poor ovarian reserve are commonly given a poor prognosis for IVF success. Standard culture media for fertilizing oocytes (unfertilized eggs) is commonly used in IVF which closely resembles tubal fluid. Efforts to create optimal culture conditions for fertilization of human embryos for women with poor quality embryos and/or repeated implantation failures have been developed at our center by using AECC. AECC involves placing a patient's fertilized eggs on top of a layer of cells from her own uterine lining, creating a more natural environment for embryo development and maximizing the chance for IVF pregnancy. The investigators will prospectively randomize young patients (≤ age 38 years) poor ovarian reserve to AECC or no AECC with standard culture media to study pregnancy outcome.

Recruitment & Eligibility

Status
TERMINATED
Sex
Female
Target Recruitment
20
Inclusion Criteria
  • Healthy women undergoing IVF at CRMI
  • Age ≤ 38 years
  • Poor ovarian reserve with antral follicle count less than 6 follicles, cycle day 2/3 FSH > 12 ng/ml, AMH < 0.5 ng/ml
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Exclusion Criteria
  • Healthy women undergoing IVF with male factor, severe endometriosis, or tubal factor infertility
  • Donor patients
  • Contraindications for the use of gonadotropins (i.e. pregnancy, lactation, undiagnosed vaginal bleeding or ovarian cysts)
  • Recent or current medical conditions where the patient is not medically stable to undergo stimulation or egg retrieval, HIV infection, diabetes, cardiovascular disease, gastrointestinal, hepatic disease, renal or pulmonary disease.
  • Any patient who is not a candidate for IVF
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Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
AECCAECC (Autologous endometrial coculture)Endometrial biopsy and Autologous endometrial coculture
No AECCno endometrial biopsy or Autologous endometrial coculture (AECC) performedRoutine procedures without AECC
Primary Outcome Measures
NameTimeMethod
Pregnancy outcome1 month
Secondary Outcome Measures
NameTimeMethod
Embryo quality1 month

Trial Locations

Locations (1)

Center for Reproducutve Medicine; Weill Cornell Medical College

🇺🇸

New York, New York, United States

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