Autologous Endometrial Coculture (AECCT)
- Conditions
- Infertility
- Interventions
- Procedure: AECC (Autologous endometrial coculture)Other: no endometrial biopsy or Autologous endometrial coculture (AECC) performed
- Registration Number
- NCT01472861
- Lead Sponsor
- Weill Medical College of Cornell University
- Brief Summary
The purpose of this study is to determine if the use of Autologous Endometrial Coculture (AECC) in young in vitro fertilization (IVF) patients with poor ovarian reserve improves pregnancy outcome.
- Detailed Description
Young women with poor ovarian reserve are commonly given a poor prognosis for IVF success. Standard culture media for fertilizing oocytes (unfertilized eggs) is commonly used in IVF which closely resembles tubal fluid. Efforts to create optimal culture conditions for fertilization of human embryos for women with poor quality embryos and/or repeated implantation failures have been developed at our center by using AECC. AECC involves placing a patient's fertilized eggs on top of a layer of cells from her own uterine lining, creating a more natural environment for embryo development and maximizing the chance for IVF pregnancy. The investigators will prospectively randomize young patients (≤ age 38 years) poor ovarian reserve to AECC or no AECC with standard culture media to study pregnancy outcome.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- Female
- Target Recruitment
- 20
- Healthy women undergoing IVF at CRMI
- Age ≤ 38 years
- Poor ovarian reserve with antral follicle count less than 6 follicles, cycle day 2/3 FSH > 12 ng/ml, AMH < 0.5 ng/ml
- Healthy women undergoing IVF with male factor, severe endometriosis, or tubal factor infertility
- Donor patients
- Contraindications for the use of gonadotropins (i.e. pregnancy, lactation, undiagnosed vaginal bleeding or ovarian cysts)
- Recent or current medical conditions where the patient is not medically stable to undergo stimulation or egg retrieval, HIV infection, diabetes, cardiovascular disease, gastrointestinal, hepatic disease, renal or pulmonary disease.
- Any patient who is not a candidate for IVF
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description AECC AECC (Autologous endometrial coculture) Endometrial biopsy and Autologous endometrial coculture No AECC no endometrial biopsy or Autologous endometrial coculture (AECC) performed Routine procedures without AECC
- Primary Outcome Measures
Name Time Method Pregnancy outcome 1 month
- Secondary Outcome Measures
Name Time Method Embryo quality 1 month
Trial Locations
- Locations (1)
Center for Reproducutve Medicine; Weill Cornell Medical College
🇺🇸New York, New York, United States