Hepatectomy With or Without the Thoraco-abdominal Approach

Completed

• Conditions: Surgery; Liver Tumors; Hepatectomy; Liver Resection
• Interventions: Procedure: Hepatectomy

• Registration Number: NCT03171428
• Lead Sponsor: University of Milan

Brief Summary

The performance of hepatectomy for liver tumors using the thoraco-abdominal approach (TAA) versus the abdominal approach (AA) is still debated.

The aim of the study is the analysis of the perioperative outcome of patients operated with or without the TAA for liver tumors.

Detailed Description

The prospectively maintained database was queried. A 1:1 propensity score-matched analysis was applied. Among 744 patients, 246 undergoing hepatectomy with TAA and 246 undergoing hepatectomy with AA were compared. These patients were matched for baseline characteristics, underlying liver disease, comorbidity, tumor features, and extent of the resection. The rates of morbidity and mortality were the study endpoints.

Study Timeline

• Study Start: 2007-01-01
• Primary Completion: 2013-12-31
• Study Completion: 2015-04-01
• Status Verified: 2017-05
• Study First Submitted: 2017-05-28
• Study First Submitted QC: 2017-05-30
• Study First Posted: 2017-05-31
• Last Update Submitted: 2017-05-31
• Last Update Posted: 2017-06-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 744

Inclusion Criteria

• First liver surgery;
• Any type of malignant liver tumor, including hepatocellular carcinoma on cirrhosis.

Exclusion Criteria

• Previous history of liver surgery;
• Any type of benign liver tumor;
• Incomplete clinical, surgical, pathological or postoperative data;
• Patients treated with radiofrequency ablation alone or in combination with surgery were also excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
AA	Hepatectomy	Abdominal Approach: those patients with liver tumors operated with the abdominal approach (without the thoracotomy)
TAA	Hepatectomy	Thoraco-Abdominal Approach: those patients with liver tumors operated with the thoracic-abdominal approach

Primary Outcome Measures

Name	Time	Method
Short-term outcome: Occurrence of postoperative complications or death after surgery	Within 90-days after the operation	Occurrence of postoperative complications or death after surgery