Comparison of Two Different Doses of Vitamin D in Preterm Infants
Not Applicable
- Conditions
- Osteopenia of Prematurity
- Interventions
- Dietary Supplement: vitamin D
- Registration Number
- NCT03889717
- Lead Sponsor
- Cairo University
- Brief Summary
randomized clinical trial comparing two different doses of vitamin d supplementation in preterm infants
- Detailed Description
after randomization each group of preterm neonates (28-32) weeks consisting of 40 neonates
within 48 hrs of birth baseline ca.phosphorus, alkaline phosphatase and vitamin D level were withdrawn from each neonate
then babies started to take oral vitamin d in different doses (400 IU /day in the 1st group and 1000 iu per day in the 2nd group) after they reach 100 cc per kg per day enteral feeding
after they complete 40th week gestational age the investigators repeat the labs again ( serum ca, phosphorus,alp and vitamin D and compare the rate of rise in vitamin D and calcium
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
- Preterm infants delivered at a gestational age ≤ 32 weeks
- Birth weight ≤1500 kg
Exclusion Criteria
- Neonates with major congenital anomalies,
- maternal condition or medications likely to influence vitamin D or calcium metabolism
- neonates not receiving 100 ml/ kg / day of enteral feeds by 14 days of life
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1000 iu vitamin D neonates who will receive vitamin d dose 1000 iu per day 400 iu vitamin D neonates who will receive vitamin d dose at 400 iu per day
- Primary Outcome Measures
Name Time Method Compare the level of serum 25 hydroxy vitamin D between the two groups of newborns. 2- Detect vitamin D deficiency among both groups. 1 month measurement of the level after supplementation
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Kasr alainy
🇪🇬Cairo, Egypt