Validation of optical rhinometry and nasal nitric oxide measurement for clinical use in allergic and non-allergic patients based on acoustic rhinometry and active anterior rhinomanometry
- Conditions
- J30.4Allergic rhinitis, unspecified
- Registration Number
- DRKS00031457
- Lead Sponsor
- DGUV, Institut für Prävention und Arbeitsmedizin (IPA) Bochum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 160
No allergies (negative prick test, negative medical history, sX1 and IgE normal)
Birch pollen allergy (matching seasonal complaints, prick test positive for early bloomers and blood serum birch pollen sensitization detectable)
House dust mite allergy (suitable seasonal complaints, prick test and proof of sensitization in serum to Derm pter. and/or farinae detectable)
active smoking
High blood pressure & medication with ACE inhibitors and/or beta blockers
pregnancy/breastfeeding
known severe reactions to histamine
history of anaphylactic reaction (allergic shock)
systemic cortisone medication < 3 weeks
medication with antihistamines < 3 weeks
Polyposis nasi
infection less than four weeks ago
local allergic rhinopathy
nonspecific nasal hyperreactivity
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The aim of the present study is to validate both optical rhinometry and nasal nitric oxide measurement. <br>Since optical rhinometry measures continuously, the hypothesis is that allergic reactions of the nose can be determined earlier and possibly more sensitively than before. With respect to nasal NO, the goal is to find a defined measurement change that defines a positive nasal provocation, similar to FeNO.
- Secondary Outcome Measures
Name Time Method Secondary endpoint is to establish, if possible, a cut-off value for a positive (allergic) nasal response for optical rhinometry.