ACTRN12614000958684招募中4 期
Does a longer course (13-14 days) of antibiotics compared to a shorter course (5-6 days), improve short and medium-term clinical outcomes of children hospitalised with severe community-acquired pneumonia
适应症
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 3 Months 至 6 Years（—）
- 性别
- All
入选标准
- •(a) Hospitalised children who have been unwell for <7-days with pneumonia
- •(b) Alveolar consolidation on CXR; and
- •(c) After 48-72 hours of IV penicillin/ampicillin the children are afebrile, with improved respiratory symptoms and signs, SpO2 >92% in air and are ready to be switched to oral antibiotics
排除标准
- •Presence of one or more:
- •(a) underlying chronic illness (not asthma): chronic lung disease of infancy, bronchiectasis, cystic fibrosis, congenital heart disease, or immunodeficiency
- •(b) complicated pneumonia (effusion, empyema, abscess); non-alveolar pneumonia; those requiring assisted ventilation or circulatory support; or where a treatment course of IV antibiotics other than penicillin/ampicillin has been used (eg. anti-staphylococcal antibiotics, cephalosporins or macrolides);
- •(c) extra-pulmonary infection requiring antibiotic therapy (eg. meningitis); or
- •(d) beta-lactam antibiotic allergy
研究者
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