Regulation of Blood Dendritic Cells During Immune Therapy for Hymenoptera Venom Allergy

Not Applicable

• Conditions: Hymenoptera Venom Allergy

• Registration Number: NCT00947908
• Lead Sponsor: University of Rostock

Brief Summary

Dendritic cells (DC) play a key role in the pathogenesis of allergic diseases. The regulation of blood dendritic cells in patients with hymenoptera venom allergy before and during immune therapy is unknown.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-06
• Status Verified: 2009-07
• Study First Submitted: 2009-07-27
• Study First Submitted QC: 2009-07-27
• Study First Posted: 2009-07-28
• Last Update Submitted: 2010-01-12
• Last Update Posted: 2010-01-13
• Primary Completion: 2010-06
• Study Completion: 2010-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Patients with diagnosed hymenoptera venom allergy
• No previous treatments for hymenoptera venom allergy

Exclusion Criteria

• Treatment with immunosuppressive agents
• Any malignant disease
• Infections within 1 week prior to the initiation of the treatment

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Number of myeloid DC and plasmacytoid DC in peripheral blood	Directly before, 1 hour after, and 12 months after initiation of immune therapy

Secondary Outcome Measures

Name	Time	Method
Surface molecule expression on myeloid DC and plasmacytoid DC	Directly before, 1 hour after, and 12 months after initiation of immune therapy

Trial Locations

Locations (1)

University of Rostock; 🇩🇪 Rostock, mecklenburg-Vorpommern, Germany