Single step treatment using radiofrequency ablation and endoscopic resection for Barrett esophagus containing early neoplasia . - Radiofrequency ablation and endoscopic resection: one treatment

Academisch Medisch Centrum0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•- Age 18-85 years;
•- Minimum circumferential extent of Barrett's of 2cm prior to treatment
•- Endoscopic visible abnormality of type 0-I,0-IIa, 0-IIc or a combination therof.
•- Biopsy proven High grade dysplasia (HGD) or Early cancer (EC) on two seperate endoscopic sampling procedures.
•- Written informed consent

•1. Barrett's extent of >12cm
•2. Any prior endoscopic treatment for esophageal adenocarcinoma of BE associated neoplasia.
•3. Signs of local or distant metastasis on EUS (EUS is obligatory).
•4. Signs of distant metastasis on CT-scan of thorax and/or abdomen (optional for mucosal lesions).
•5. Any of the following findings in any of the ER specimens: G3 or G4 tumor differentiation; lymphatic invasion; infiltration into the submucosa >500µm, a positive deeper resection margin.
•6. Endoscopic signs of esophageal varices.
•7. Esophageal stenosis not allowing passage of a therapeutic endoscope with an ER-cap.
•8. Prior esophageal surgery (except fundoplication).
•9. Use of any anticoagulant therapy that can not be discontinued between one week before and 1 week after every treatment session.

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