MSG and Gastrointestinal Motility
- Conditions
- Gastroesophageal Reflux
- Interventions
- Dietary Supplement: Sodium chlorideDietary Supplement: Monosodium glutamate
- Registration Number
- NCT01009658
- Lead Sponsor
- Gunma University
- Brief Summary
The purpose of this study is to clarify the physiological function of sodium glutamate by measuring its effect on upper GI motility ( gastric emptying).
- Detailed Description
Amino acids such as monosodium glutamate are known to stimulate both endocrine and exocrine secretion. In addition, there is a report that oral intake of glutamate evokes the activation of vagal afferent nerves in the rat. Thus, such amino acids are thought to be influential in the process of digestion and absorption.
. To investigate the effect of monosodium glutamate on gastrointestinal motility, we planned a single-blind randomized study. The participants will take either monosodium glutamate or sodium chloride before the first examination of upper GI motility and the other agent before the second examination. The order of intake will be randomized by the envelope method.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- Healthy subjects
- Must not have digestive symptoms
- Must not eat within six hours of study participation
- Regular medications for the gastrointestinal tract
- Previous Helicobacter pylori infection
- Previous abdominal surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description NaCl first Sodium chloride - MSG first Monosodium glutamate -
- Primary Outcome Measures
Name Time Method Gastric emptying 0-5 hours half emptying time
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Gunma university hospital
🇯🇵Maebashi, Gunma, Japan