Randomized Clinical Trial of Ivabradine to Reduce Heart Rate Prior to Coronary CT-angiography in Advanced Heart Failure: Comparison With β-Blocker

Rajaie Cardiovascular Medical and Research Center1 site in 1 country200 target enrollmentNovember 26, 2018

ConditionsHeart Failure CT Angiography Ischemic Cardiomyopathy Non-ischemic Cardiomyopathy Heart Failure, Systolic Heart Failure，Congestive Heart Failure, Diastolic Heart Rate Low

InterventionsIvabradine Metoprolol

DrugsIvabradine Metoprolol

Overview

Phase: Not Applicable
Intervention: Ivabradine
Conditions: Heart Failure
Sponsor: Rajaie Cardiovascular Medical and Research Center
Enrollment: 200
Locations: 1
Primary Endpoint: Heart rate
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of this study is to compare the effects of Ivabradine and metoprolol to reduce heart rate prior to coronary CT angiography in patients with advanced heart failure.

Registry

clinicaltrials.gov

Start Date

November 26, 2018

End Date

December 2019

Last Updated

7 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Rajaie Cardiovascular Medical and Research Center

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Sinus rhythm
•Heart rate \>60/min

Exclusion Criteria

•Atrial fibrillation
•Any contraindication for beta-blocker use

Arms & Interventions

Ivabradine

Intervention: Ivabradine

metoprolol

Intervention: Metoprolol

Outcomes

Primary Outcomes

Heart rate

Time Frame: 30 minutes before and after coronary CT angiography

Changing heart rate during imaging study

Secondary Outcomes

Dyspnea(30 minutes before and after coronary CT angiography and 6 months later)
Blood pressure, systolic and diastolic(30 minutes before and after coronary CT angiography and 6 months later)
Hypotension(30 minutes before and after coronary CT angiography)
Sleep quality(Before CT angiography and 6 months later)
Functional calss(30 minutes before and after coronary CT angiography and 6 months later)
Appetite(Before CT angiography and 6 months later)
Prolonged bradycardia(30 minutes before and after coronary CT angiography)