Effect of platelet rich plasma and silver ion dressing on venous ulcer healing

Completed

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/04/051654
• Lead Sponsor: Institute of medical sciences

Brief Summary

Venous ulcer is a common public health problem. Venous leg ulcer healing process is complex as it affects both macro and micro vasculature. Autologous platelet rich plasma being a rich source of growth factors, may be effective. It is safe, easy to prepare and cost effective. On the other hand the microbicidal action of silver ions has also been tried for ulcer healing. In our study patients with venous leg ulcer will be treated by topical application of PRP and silver ion dressing and the rate of ulcer healing compared over a duration of 6 weeks. Quality of life assessment will also be done by the use of Aberdeen varicose vein questionnaire.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-04-25
• Study Completion: 2024-01-07
• Last Update Posted: 2024-03-08

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Venous leg ulcer with ABPI more than 0.8 with normal platelet count.
• VLU grading 0-5A & 6A ( according to modified TIME-H score).

Exclusion Criteria

• Modified TIME-H score [5B & 6B-8 (healing unlikely) 2.
• VLU area > 100sq cm 3.
• Immune-compromised 4.
• Coagulation disorders.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
comparing effect of topical platelet rich plasma and silver ion on venous ulcer healing	6 weeks

Secondary Outcome Measures

Name	Time	Method
Improvement in pain score	6 weeks

Trial Locations

Locations (1)

Sir Sunder Lal Hospital; 🇮🇳 Varanasi, UTTAR PRADESH, India

Sir Sunder Lal Hospital

🇮🇳Varanasi, UTTAR PRADESH, India

Prof Seema Khanna

Principal investigator

8318332113

seemakhanna119@rediffmail.com