The relationship between lung ultrasound imaging and oxygenation during alveolar recruitment manoeuvres in neonates receiving high frequency oscillatory ventilation.

Not Applicable

Recruiting

• Conditions: eonatal respiratory distress; Lung recruitment; Neonatal respiratory distress; Respiratory - Other respiratory disorders / diseases; Reproductive Health and Childbirth - Complications of newborn

• Registration Number: ACTRN12622001009707
• Lead Sponsor: The Royal Women's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-07-19
• Last Update Posted: 1 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

All infants who are on HFOV less than or equal to 0.3 FiO2 with recruitable lung disease. This includes but is not limited to:

•Respiratory distress syndrome related to surfactant deficiency
•Acute respiratory distress syndrome secondary to acquired lung inflammation
•Meconium aspiration syndrome
•Pneumonia
•Preterm infants post abdominal surgery

Exclusion Criteria

Any infant in which alveolar recruitment would be contra-indicated, these include:

•Clinician concern regarding clinical stability
•Primary pulmonary hypertension without parenchymal lung disease
•Congenital lung malformations including congenital diaphragmatic hernia
•Pulmonary hypoplasia
•Cystic chronic lung disease
•Air leak including pneumothorax and pulmonary interstitial emphysema
•Hydrops fetalis or large pleural effusions
•Hypotensive despite appropriate cardiovascular support
•Skin integrity will not tolerate ultrasound gel

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
S scores during the ARM which will be blindly reported by the study investigators [ At each increment of the ARM]

Secondary Outcome Measures

Name	Time	Method
End expiratory lung volume (EELV) determined using EIT <br><br><br>[ At each increment of the ARM];SpO2 measured by pulse oximetry<br>[ At each increment of the ARM];Mean airway pressure measured by the ventilator[ At each increment of the ARM];Oxygen saturation index (OSI) which will be determined by the measured SpO2 and fraction of inspired oxygen[ At each increment of the ARM];Fraction of inspired oxygen (FiO2) as measured by the ventilator[ At each increment of the ARM];Tidal volume as measured by the ventilator[ At each increment of the ARM];Oscillatory amplitude as measured by the ventilator[ At each increment of the ARM];Carbon dioxide diffusion coefficient (DCO2) as measured by the ventilator[ At each increment of the ARM];Transcutaneous partial pressure of carbon dioxide (TCO2) as measured from the monitoring systems [ At each increment of the ARM];Transcutaneous partial pressure of oxygen (TO2) as measured from the monitoring systems[ At each increment of the ARM]