Intralipid Related Effect on NKcells in Patients With Unexplained Recurrent Spontaneous Abortion
- Registration Number
- NCT03132779
- Lead Sponsor
- Ahmed Mohamed Bahaa Eldin Ahmed
- Brief Summary
Evaluating the effect of intralipid on the natural killer cells
- Detailed Description
This study will done on women with recurrent spontaneous abortions having increased NKCELLS activity and evaluate the effect of Intralipid on them after re-estimation of NKcells activity again after one week of Intralipid adminstration
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 34
Inclusion Criteria
- All women icluded having recurrent spontaneous abortions equal or more than twice.
- Alittle women having increased NKCELLS activity.
Exclusion Criteria
- Any other diseases causing miscarriage as autoimmune (lupus erythematosus or antiphospholipid antibodies syndrome )or endocrinopathy (diabetes mellitus, thyroid disorders and hyperprolactinaemia)or thrombophilia (factor v leiden mutation, protein c or s deficiency, prothrombin G20210A mutation, antithrombin III deficiency ) or abnormal karyotyping to one or both of parents or previous history of hormonal contraception or intrauterine device usage at last 3 months or any contraindications for intralipid usage.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description One armed Intralipid One group of patient will take Intralipid for all
- Primary Outcome Measures
Name Time Method Change in NK cells activity after injection of intralipid One week NK cells is measured before and after injection of intralipid and is noticed for change in activity
- Secondary Outcome Measures
Name Time Method