NCT03132779UnknownPhase 1
Intralipid Related Effect on NKcells in Patients With Unexplained Recurrent Spontaneous Abortions
Ahmed Mohamed Bahaa Eldin Ahmed0 sites34 target enrollmentStarted: May 1, 2017Last updated:
Conditions
Interventions
Drugs
Trial Snapshot
- Phase
- Phase 1
- Sponsor
- Enrollment
- 34
- Primary Endpoint
- Change in NK cells activity after injection of intralipid
Study Overview
Brief Summary
Evaluating the effect of intralipid on the natural killer cells
Detailed Description
This study will done on women with recurrent spontaneous abortions having increased NKCELLS activity and evaluate the effect of Intralipid on them after re-estimation of NKcells activity again after one week of Intralipid adminstration
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 38 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •All women icluded having recurrent spontaneous abortions equal or more than twice.
- •Alittle women having increased NKCELLS activity.
Exclusion Criteria
- •Any other diseases causing miscarriage as autoimmune (lupus erythematosus or antiphospholipid antibodies syndrome )or endocrinopathy (diabetes mellitus, thyroid disorders and hyperprolactinaemia)or thrombophilia (factor v leiden mutation, protein c or s deficiency, prothrombin G20210A mutation, antithrombin III deficiency ) or abnormal karyotyping to one or both of parents or previous history of hormonal contraception or intrauterine device usage at last 3 months or any contraindications for intralipid usage.
Arms & Interventions
One armed
Experimental
One group of patient will take Intralipid for all
Intervention: Intralipid (Drug)
Outcomes
Primary Outcomes
Change in NK cells activity after injection of intralipid
Time Frame: One week
NK cells is measured before and after injection of intralipid and is noticed for change in activity
Secondary Outcomes
No secondary outcomes reported
Investigators
Ahmed Mohamed Bahaa Eldin Ahmed
Clinical professor
Ain Shams Maternity Hospital
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