Do Beta-blockers Affect the Use of Beta-agonist Inhalers in COPD?
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Waikato Hospital
- Enrollment
- 11
- Locations
- 1
- Primary Endpoint
- Incremental Shuttle Walk Test Result after taking beta-blockers
Study Overview
Brief Summary
Smoking causes both smoking related lung disease (COPD) and ischaemic heart disease. These are very common conditions and many patients have both diseases. Beta-blocker drugs are extensively used in the treatment of angina, high blood pressure and after heart attacks to decrease symptoms and prolong life. Beta-agonists are used in COPD to decrease breathlessness and improve exercise tolerance. It used to be thought that beta-blockers cannot be used in COPD patients as they may make the breathlessness worse, but it has now been established that they can be used safely. Beta-blocker drugs and beta-agonists have 'opposite' effects on the body and the investigators do not know if they can work together or if they would cancel each other out. The investigators also do not know which of the different types of beta-blockers now available are better for COPD patients. This study will investigate what happens to the airways of people taking both of these drugs.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 40 Years to 100 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Clinical diagnosis of COPD
- •> 40 years of age
- •> 15 pack year smoking history
Exclusion Criteria
- •Contra-indication to beta-blocker use
- •Severe COPD FEV1 < 30% or 1 L
- •Not responsive the methacholine
Arms & Interventions
R302
Daily placebo capsules
Intervention: bronchodilator response (Drug)
R303
Daily metoprolol 95mg capsules
Intervention: bronchodilator response (Drug)
R304
Daily propranolol 80mg capsules
Intervention: bronchodilator response (Drug)
Open Label
Daily Metoprolol 190mg capsules
Intervention: bronchodilator response (Drug)
Outcomes
Primary Outcomes
Incremental Shuttle Walk Test Result after taking beta-blockers
Time Frame: 7-10 days
Bronchodilator response to salbutamol after beta-blockers
Time Frame: 7-10 days
Secondary Outcomes
No secondary outcomes reported