Investigating the Effects of Beta-Hydroxy-Beta-Methylbutyrate on Glucose Handling in Older and Younger Men.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Nottingham
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Matsuda Index of insulin sensitivity
Study Overview
Brief Summary
This study intends to examine the effect of a commercially available nutritional supplement, Beta-hydroxy-beta-methylbutyrate(HMB) on whole-body responses to a sugar load.
Detailed Description
One change associated with human aging is a reduction in "fitness", both in terms of how far or quickly a person can run/cycle/swim and also in how well their blood vessels work. Additionally a person's metabolic fitness decreases; this is how well the body copes with nutrition and is why, for example, older people have a higher risk of diseases like type 2 diabetes. Previous studies have shown that as people become less fit, they are at increased risk of suffering a complication whilst undergoing surgery. It has also been shown that measuring how fit someone is, is better at predicting the risk of a surgical complication than purely using a person's age alone. Lots of research has shown that exercise can potentially reverse some of the age-related declines in fitness, however most has used long sessions of continuous exercise over a long period of time. High-intensity interval training (HIT), whereby people cycle on an exercise bike very hard for a minute, followed by a short rest, repeated over the course of 15 minutes can rapidly improve a person's fitness. However not everyone will be able to, or indeed want to participate in exercise this strenuous; therefore this research seeks to explore whether other options, such as dietary supplements can improve aspects of fitness
This study intends to examine the effect of giving a dietary supplement on the way a person's body handles the glucose (from carbohydrates/ sugars) in a meal. Previous work has shown that taking a beta-hydroxy beta-methyl butyrate (HMB) supplement may improve may improve a patient's response to glucose, however the evidence is not clear. HMB is a commercially available nutritional supplement providing a compound that the body produces each time protein is consumed, and is most commonly used by bodybuilders to help gain muscle.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Prevention
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 85 Years (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy volunteers
- •Aged 18-35 or 65-85
Exclusion Criteria
- •Current participation in a formal exercise regime
- •A BMI < 18 or > 32 kg·m2
- •Active cardiovascular disease:
- •o uncontrolled hypertension (BP > 160/100), angina, heart failure (class III/IV), Significant arrhythmia, right to left cardiac shunt, recent cardiac event
- •Taking beta-adrenergic blocking agents,
- •Cerebrovascular disease:
- •o previous stroke, aneurysm (large vessel or intracranial), epilepsy
- •Respiratory disease including:
- •o pulmonary hypertension, significant COPD, uncontrolled asthma,
- •Metabolic disease:
- •o hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, type 1 or 2 diabetes
- •Active inflammatory bowel or renal disease
- •Malignancy
- •Clotting dysfunction
- •Significant musculoskeletal or neurological disorders
- •Family history of early (<55y) death from cardiovascular disease
Arms & Interventions
Older Men
Healthy male adults aged 18-35 Subjects will receive both HMB and placebo on separate visits in a crossover fashion
Intervention: Placebo (Other)
Younger Men
Healthy male adults aged 65-85 Subjects will receive both HMB and placebo on separate visits in a crossover fashion
Intervention: Placebo (Other)
Younger Men
Healthy male adults aged 65-85 Subjects will receive both HMB and placebo on separate visits in a crossover fashion
Intervention: Beta-Hydroxy-Beta-Methylbutyrate (Dietary Supplement)
Older Men
Healthy male adults aged 18-35 Subjects will receive both HMB and placebo on separate visits in a crossover fashion
Intervention: Beta-Hydroxy-Beta-Methylbutyrate (Dietary Supplement)
Outcomes
Primary Outcomes
Matsuda Index of insulin sensitivity
Time Frame: 180 minutes after a 75g oral glucose load
Assessed from arterialised venous blood samples
Cederholm index of insulin sensitivity
Time Frame: 180 minutes after a 75g oral glucose load
Assessed from arterialised venous blood samples
Secondary Outcomes
- Area-Under-Curve Insulin Concentration(180 minutes after a 75g oral glucose load)
- Area-Under-Curve Glucose Concentration(180 minutes after a 75g oral glucose load)
- Femoral Artery Blood flow(15 minutes, 60 minutes and 120 minutes after a 75g oral glucose load)